Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children.
Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children.
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年轻墨西哥裔美国儿童的有机磷酸农药暴露和神经发育。
DOI：
10.1289/ehp.9828
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发表时间：
2007-05
影响因子：
10.4
通讯作者：
Jewell, Nicholas A.
中科院分区：
文献类型：
--
作者：
Eskenazi, Brenda;Marks, Amy R.;Bradman, Asa;Harley, Kim;Barr, Dana B.;Johnson, Caroline;Morga, Norma;Jewell, Nicholas A.
关键词：
有机磷农药广泛应用于农业和家庭。动物研究表明，即使是中等剂量也是神经发育毒物，但在人类中的研究很少。我们调查了产前和儿童尿OP代谢产物水平与儿童神经发育的关系。参与研究的儿童主要来自加州拉丁裔农场工人家庭的纵向出生队列。我们测量了六个非特异性二烷基磷酸盐（DAP）的代谢物在母亲和儿童的尿液，以及代谢物的具体马拉硫磷（MDA）和毒死蜱（TCPy）在母亲的尿液。我们研究了它们与儿童在6（n = 396），12（n = 395）和24（n = 372）个月时的贝利婴儿发展量表[心理发展（MDI）和精神发育（PDI）指数]和母亲对儿童行为检查表（CBCL）的报告（n = 356）的关系。一般来说，妊娠DAP水平与MDI呈负相关，但儿童措施呈正相关。在24个月大时，这些相关性达到统计学显著性[产前DAP每增加10倍：β = −3.5点; 95%置信区间（CI），−6.6至−0.5;儿童DAP：β = 2.4点; 95% CI，0.5至4.2]。产前和儿童DAPs与PDI或CBCL注意力问题无关，但产前和产后DAPs均与广泛性发育障碍的风险相关[产前DAPs每增加10倍：比值比（OR）= 2.3，p = 0.05;儿童DAPs OR = 1.7，p = 0.04]。MDA和TCPy与任何结果无关。我们报告了产前DAP与24个月大时的智力发育和普遍性发育问题的不良关联。鉴于观察到的与产后DAP的正相关性，应谨慎解释结果。
Organophosphate (OP) pesticides are widely used in agriculture and homes. Animal studies suggest that even moderate doses are neurodevelopmental toxicants, but there are few studies in humans. We investigated the relationship of prenatal and child OP urinary metabolite levels with children’s neurodevelopment. Participating children were from a longitudinal birth cohort of primarily Latino farm-worker families in California. We measured six nonspecific dialkylphosphate (DAP) metabolites in maternal and child urine as well as metabolites specific to malathion (MDA) and chlorpyrifos (TCPy) in maternal urine. We examined their association with children’s performance at 6 (n = 396), 12 (n = 395), and 24 (n = 372) months of age on the Bayley Scales of Infant Development [Mental Development (MDI) and Psychomotor Development (PDI) Indices] and mother’s report on the Child Behavior Checklist (CBCL) (n = 356). Generally, pregnancy DAP levels were negatively associated with MDI, but child measures were positively associated. At 24 months of age, these associations reached statistical significance [per 10-fold increase in prenatal DAPs: β = −3.5 points; 95% confidence interval (CI), −6.6 to −0.5; child DAPs: β = 2.4 points; 95% CI, 0.5 to 4.2]. Neither prenatal nor child DAPs were associated with PDI or CBCL attention problems, but both prenatal and postnatal DAPs were associated with risk of pervasive developmental disorder [per 10-fold increase in prenatal DAPs: odds ratio (OR) = 2.3, p = 0.05; child DAPs OR = 1.7, p = 0.04]. MDA and TCPy were not associated with any outcome. We report adverse associations of prenatal DAPs with mental development and pervasive developmental problems at 24 months of age. Results should be interpreted with caution given the observed positive relationship with postnatal DAPs.
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影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
在多种族的城市队列中，怀孕期间室内农药接触。
影响因子：
10.4
作者：
Berkowitz, Gertrud S;Obel, Josephine;Deych, Elena;Lapinski, Robert;Godbold, James;Liu, Zhisong;Landrigan, Philip J;Wolff, Mary S
通讯作者：
Wolff, Mary S
影响因子：
2.5
作者：
Bravo, R;Driskell, WJ;Barr, DB
通讯作者：
Barr, DB
影响因子：
10.4
作者：
Bradman A;Eskenazi B;Barr DB;Bravo R;Castorina R;Chevrier J;Kogut K;Harnly ME;McKone TE
通讯作者：
McKone TE
影响因子：
10.4
作者：
Castorina, R;Bradman, A;Eskenazi, B
通讯作者：
Eskenazi, B