Epigenetic enzymes are the therapeutic targets for CD4(+)CD25(+/high)Foxp3(+) regulatory T cells.
Epigenetic enzymes are the therapeutic targets for CD4(+)CD25(+/high)Foxp3(+) regulatory T cells.
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DOI：
10.1016/j.trsl.2014.08.001
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Yang XF
中科院分区：
文献类型：
--
作者：
Lopez-Pastrana J;Shao Y;Chernaya V;Wang H;Yang XF
CD 4 + CD 25 +/highFoxp 3+调节性T细胞（Treg）是在维持外周免疫耐受中起重要作用的CD 4 + T细胞亚群。最近已经鉴定了几种转录辅因子，它们与TclO转录因子Foxp 3形成复合物并有助于TclO的抑制功能。然而，Foxp 3仍然被定义为控制TcB发育和稳定性的“主”（多途径）调节基因。由于其重要性，Foxp 3表达的调控机制一直是深入研究的焦点。最近的进展表明，负责调节Foxp 3基因表达的表观遗传学机制是TGFAP抑制活性的关键组成部分。这篇综述不仅讨论了生物学和表观遗传修饰的基本概念。我们还分析了转基因表观遗传修饰的临床方面，重点是几个正在进行的临床试验以及FDA批准的表观遗传药物。在鉴定Treg细胞中有功能的表观遗传酶方面的新进展是开发用于自身免疫性疾病和炎性疾病、移植物抗宿主病和癌症的新治疗方法的新靶点。
CD4+CD25+/highFoxp3+ regulatory T cells (Tregs) are a subset of CD4+ T cells that play an essential role in maintaining peripheral immune tolerance. Several transcriptional co-factors have been recently identified, which form complexes with Tregs transcription factor Foxp3 and contribute in the suppressive function of Tregs. However, Foxp3 is still defined as a “master” (multiple pathway) regulator gene that controls the development and stability of Tregs. Due to its importance, the regulatory mechanisms underlying Foxp3 expression have been a focus of intensive investigation. Recent progress suggests that the epigenetics mechanisms responsible for regulating the Foxp3 gene expression are key components of Tregs suppressive activity. This review not only discusses the basic concepts of Tregs biology and epigenetic modifications. We also analyze the translational clinical aspect of Tregs epigenetic modifications, focusing on several ongoing clinical trials as well as FDA approved epigenetic based drugs. The new progress in identifying epigenetic enzymes functional in Treg cells is a new target for the development of novel therapeutic approaches for autoimmune and inflammatory diseases, graft-versus-host disease and cancers.
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影响因子：
82.9
作者：
Ait-Oufella, H;Salomon, BL;Mallat, Z
通讯作者：
Mallat, Z
DOI：
10.1111/j.1600-0897.2005.00330.x
发表时间：
2005-12-01
影响因子：
3.6
作者：
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通讯作者：
Curiel, TJ
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10.1161/atvbaha.110.206813
发表时间：
2010-09-01
影响因子：
8.7
作者：
Ammirati, Enrico;Cianflone, Domenico;Norata, Giuseppe Danilo
通讯作者：
Norata, Giuseppe Danilo
组蛋白脱乙酰基酶6和9和Sirtuin-1控制FOXP3+调节性T细胞功能通过共享和同工型特异性机制。
影响因子：
7.3
作者：
Beier UH;Wang L;Han R;Akimova T;Liu Y;Hancock WW
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Hancock WW
DOI：
10.1073/pnas.51.5.786
发表时间：
1964-01-01
影响因子：
11.1
作者：
ALLFREY, VG;FAULKNER, R;MIRSKY, AE
通讯作者：
MIRSKY, AE