Research Progress on Polydopamine Nanoparticles for Tissue Engineering.

Research Progress on Polydopamine Nanoparticles for Tissue Engineering.
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聚多巴胺纳米粒子在组织工程中的研究进展。

DOI:
10.3389/fchem.2021.727123
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发表时间:
2021
影响因子:
5.5
通讯作者:
Zhu M
Zhu M
中科院分区:
化学3区
文献类型:
--
作者:
Tang Y;Tan Y;Lin K;Zhu M

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组织工程是一个跨学科的领域,旨在开发生物替代品,以替代,修复或增强组织功能。生物材料的物理和化学特性对生物反应和随后的生物功能有着深远的影响。纳米结构涂层作为一种有效的表面改性手段,在提高生物材料生物活性方面得到了广泛的应用。特别地,发现聚多巴胺和聚多巴胺衍生的纳米颗粒除了具有优异的生物相容性和亲水性之外,还具有过量的氧化还原活性、光热转换能力、顺磁性和导电性。本文综述了聚多巴胺纳米颗粒在骨、软骨、皮肤、心脏、神经等组织工程中的应用研究进展,为今后生物材料的设计提供参考。
Tissue engineering is an interdisciplinary field that aims to develop biological substitutes for the replacement, repair, or enhancement of tissue function. The physical and chemical characteristics of biomaterials exert a profound influence on the biological responses and the following biofunction. Nanostructured coatings have been widely applied as an effective surface modification strategy to improve the bioactivity of biomaterials. Especially, polydopamine and polydopamine-derived nanoparticles are found with excessive adhesiveness, redox activity, photothermal conversion capacity, paramagnetism and conductivity other than excellent biocompatibility, and hydrophilicity. In this article, advances about polydopamine nanoparticles in tissue engineering applications are reviewed, including the repair of bone, cartilage, skin, heart, and nerve, to provide strategies for future biomaterial design.
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