Circadian regulation of pulmonary disease: the importance of timing.
Circadian regulation of pulmonary disease: the importance of timing.
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DOI：
10.1042/cs20220061
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发表时间：
2023-06-14
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
作者：
昼夜节律调节导致生物过程的活动在24小时周期内变化。这种变异的病理学影响主要使用两种不同的方法进行研究：临床前模型或观察性临床研究。这两种方法都为了解潜在的昼夜节律机制如何运作提供了有用的见解，特别是由分子振荡器（体内关键的计时机制）调节的机制。这篇综述比较了这两种方法在四种常见呼吸系统疾病（哮喘、慢性阻塞性肺疾病、肺纤维化和呼吸道感染）中的发现。还讨论了用于识别和测量人类昼夜节律振荡的潜在方法，因为这些方法将在未来针对昼夜节律机制的干预性人体试验中成为有用的结果指标。
Circadian regulation causes the activity of biological processes to vary over a 24-h cycle. The pathological effects of this variation are predominantly studied using two different approaches: pre-clinical models or observational clinical studies. Both these approaches have provided useful insights into how underlying circadian mechanisms operate and specifically which are regulated by the molecular oscillator, a key time-keeping mechanism in the body. This review compares and contrasts findings from these two approaches in the context of four common respiratory diseases (asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, and respiratory infection). Potential methods used to identify and measure human circadian oscillations are also discussed as these will be useful outcome measures in future interventional human trials that target circadian mechanisms.
影响因子：
4.4
作者：
Kim JS;Dashti HS;Huang T;Cade BE;Podolanczuk AJ;O'Hearn DJ;Hoffman EA;Wang H;Blaikley J;Barr RG;Redline S
通讯作者：
Redline S
DOI：
10.3904/kjim.2012.27.4.426
发表时间：
2012-12
期刊：
The Korean journal of internal medicine
影响因子：
--
作者：
Kim YJ;Lee BK;Jung CY;Jeon YJ;Hyun DS;Kim KC;Yu SK;Choi HS;Shin WH;Lee KH
通讯作者：
Lee KH
影响因子：
3.7
作者：
Dequéant ML;Ahnert S;Edelsbrunner H;Fink TM;Glynn EF;Hattem G;Kudlicki A;Mileyko Y;Morton J;Mushegian AR;Pachter L;Rowicka M;Shiu A;Sturmfels B;Pourquié O
通讯作者：
Pourquié O