Patient's perception of symptoms related to morning activity in chronic obstructive pulmonary disease: the SYMBOL Study.
Patient's perception of symptoms related to morning activity in chronic obstructive pulmonary disease: the SYMBOL Study.
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DOI：
10.3904/kjim.2012.27.4.426
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Lee KH
中科院分区：
文献类型：
--
作者：
Kim YJ;Lee BK;Jung CY;Jeon YJ;Hyun DS;Kim KC;Yu SK;Choi HS;Shin WH;Lee KH
慢性阻塞性肺疾病（COPD）患者会出现更多的呼吸道症状，并且在早晨进行日常活动时遇到更多困难。本研究的目的是评估严重气流受限患者对与晨间活动相关的COPD症状的感知。在一项前瞻性、非干预性研究中分析了133例严重气流受限患者的数据。患者在基线时完成临床症状问卷。在出现晨间症状（定义为晨间活动期间至少出现一种或多种突出或加重症状）的患者中，还在基线时和COPD治疗2个月后完成晨间活动问卷。最常报告的COPD症状是呼吸困难（90.8%）。76例（57%）患者报告了早晨症状;这些患者的COPD临床症状更频繁和严重。最常报告的早晨活动是起床（82.9%）。长效毒蕈碱拮抗剂（比值比[OR]，6.971; 95%置信区间[CI]，1.317至11.905）和胸闷（OR，0.075; 95% CI，0.011至0.518）与无晨起症状显著相关。治疗2个月后，1秒用力呼气量改善程度与晨间活动各项目严重程度评分差异无显著相关性。57%的严重气流受限的COPD患者有早晨症状，限制了他们的早晨活动。这些患者也有更普遍和严重的COPD症状。因此，本研究的结果为COPD患者报告结局的发展提供了有价值的信息。
Patients with chronic obstructive pulmonary disease (COPD) experience more problematic respiratory symptoms and have more trouble performing daily activities in the morning. The aim of this study was to assess the perception of COPD symptoms related to morning activities in patients with severe airflow limitation. Data of 133 patients with severe airflow limitation were analyzed in a prospective, non-interventional study. A clinical symptom questionnaire was completed by patients at baseline. In patients having morning symptoms, defined by at least one or more prominent or aggravating symptom during morning activities, a morning activity questionnaire was also completed at baseline and following 2 months of COPD treatment. The most frequently reported COPD symptom was breathlessness (90.8%). Morning symptoms were reported in 76 (57%) patients; these had more frequent and severe clinical COPD symptoms. The most frequently reported morning activity was getting out of bed (82.9%). The long acting muscarinic antagonist (odds ratio [OR], 6.971; 95% confidence interval [CI], 1.317 to 11.905) and chest tightness (OR, 0.075; 95% CI, 0.011 to 0.518) were identified as significantly related to absence of morning symptoms. There was no significant correlation between the degree of forced expiratory volume in 1 second improvement and severity score differences of all items of morning activity after 2-month treatment. Fifty-seven percent of COPD patients with severe airflow limitation have morning symptoms that limit their morning activities. These patients also have more prevalent and severe COPD symptoms. The results of this study therefore provide valuable information for the development of patient-reported outcomes in COPD.
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影响因子：
24.3
作者：
Kessler, R.;Partridge, M. R.;Ostinelli, J.
通讯作者：
Ostinelli, J.
影响因子：
2.5
作者：
McCarley, Cynthia;Hannernan, Sandra K.;Smolensky, Michael H.
通讯作者：
Smolensky, Michael H.
影响因子：
3.7
作者：
Cazzola, Mario;Bettoncelli, Germano;Biscione, Gianluca
通讯作者：
Biscione, Gianluca
DOI：
10.1164/ajrccm/146.4.935
发表时间：
1992-10-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
KILLIAN, KJ;LEBLANC, P;CAMPBELL, EJM
通讯作者：
CAMPBELL, EJM
影响因子：
3.7
作者：
Benzo, Roberto P.;Chang, Chung-Chou H.;Sciurba, Frank
通讯作者：
Sciurba, Frank