The evolution and expression of the snaR family of small non-coding RNAs.
The evolution and expression of the snaR family of small non-coding RNAs.
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DOI：
10.1093/nar/gkq856
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发表时间：
2011-03
影响因子：
14.9
通讯作者：
Mathews MB
中科院分区：
文献类型：
--
作者：
Parrott AM;Tsai M;Batchu P;Ryan K;Ozer HL;Tian B;Mathews MB
我们最近确定了snaR家族的小非编码RNA，在体内与核因子90（NF 90/ILF 3）蛋白。主要的人类物种snaR-A是一种RNA聚合酶III转录物，在黑猩猩中具有有限的组织分布和直系同源物，但在恒河猴或小鼠中没有。我们报告了它们在人体组织中的表达及其在灵长类动物中的进化。snaR基因只存在于非洲类人猿中，有些是人类独有的。在灵长类动物中发现了两个新的snaR相关遗传元件家族：CAS（snaR的卡他鼻祖先），仅限于旧大陆猴和猿; ASR（Alu/snaR相关），存在于所有猴和猿中。ASR和CAS似乎通过逆转录转座传播，而大多数snaR基因通过节段性复制传播。snaR-A和snaR-G2在人脑和其它组织（特别是包括睾丸）的离散区域中差异表达。snaR-A在转化的和永生化的人细胞中上调，并且稳定地结合到HeLa细胞中的核糖体。我们推断，snaR进化的灵长类动物特异性铝SINE家族通过ASR和CAS与主要的灵长类动物物种形成事件的左单体，并建议snaR参与组织和物种特异性调节细胞的生长和翻译。
We recently identified the snaR family of small non-coding RNAs that associate in vivo with the nuclear factor 90 (NF90/ILF3) protein. The major human species, snaR-A, is an RNA polymerase III transcript with restricted tissue distribution and orthologs in chimpanzee but not rhesus macaque or mouse. We report their expression in human tissues and their evolution in primates. snaR genes are exclusively in African Great Apes and some are unique to humans. Two novel families of snaR-related genetic elements were found in primates: CAS (catarrhine ancestor of snaR), limited to Old World Monkeys and apes; and ASR (Alu/snaR-related), present in all monkeys and apes. ASR and CAS appear to have spread by retrotransposition, whereas most snaR genes have spread by segmental duplication. snaR-A and snaR-G2 are differentially expressed in discrete regions of the human brain and other tissues, notably including testis. snaR-A is up-regulated in transformed and immortalized human cells, and is stably bound to ribosomes in HeLa cells. We infer that snaR evolved from the left monomer of the primate-specific Alu SINE family via ASR and CAS in conjunction with major primate speciation events, and suggest that snaRs participate in tissue- and species-specific regulation of cell growth and translation.
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影响因子：
3.4
作者：
Hallast, Pille;Saarela, Janna;Laan, Maris
通讯作者：
Laan, Maris
影响因子：
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Gogolevskaya, IK;Koval, AP;Kramerov, DA
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Alu RNP和Alu RNA在体外调节翻译起始。
影响因子：
14.9
作者：
Haesler, Julien;Strub, Katharina
通讯作者：
Strub, Katharina
影响因子：
4.7
作者：
Iacoangeli, A;Lin, Y;Tiedge, H
通讯作者：
Tiedge, H