Metabolism as an integral cog in the mammalian circadian clockwork.
Metabolism as an integral cog in the mammalian circadian clockwork.
复制标题
DOI：
10.3109/10409238.2013.786672
复制
发表时间：
2013-07
影响因子：
6.5
通讯作者：
Young ME
中科院分区：
文献类型：
--
作者：
Gamble KL;Young ME
昼夜节律是生命中不可或缺的一部分。这些节律在迄今为止几乎所有的生物过程研究中都是明显的，从单个细胞（例如，DNA合成）到整个生物体（例如，如身体活动）。代谢中的振荡在包括哺乳动物在内的各种生物体中广泛存在。这些代谢节律通常与每天发生的睡眠/觉醒和禁食/进食周期等行为平行。在过去的几十年里，越来越清楚的是，许多代谢振荡是由细胞自主生物钟驱动的，细胞自主生物钟以时间适当的方式协调代谢过程。在确定生物钟影响代谢的机制的过程中，基于分子的研究表明，代谢应被视为生物钟的组成部分。这种相互关系的含义包括在心脏代谢疾病状态期间建立恶性循环，其中代谢诱导的昼夜节律钟扰动加剧代谢功能障碍。因此，本次审查的目的是突出最近的见解获得细胞自主生物钟和代谢之间的联系，和时钟功能障碍的心脏代谢疾病的发病机制的影响。
Circadian rhythms are an integral part of life. These rhythms are apparent in virtually all biological processes studies to date, ranging from the individual cell (e.g., DNA synthesis) to the whole organism (e.g., behaviors such as physical activity). Oscillations in metabolism have been characterized extensively in various organisms, including mammals. These metabolic rhythms often parallel behaviors such as sleep/wake and fasting/feeding cycles that occur on a daily basis. What has become increasingly clear over the past several decades is that many metabolic oscillations are driven by cell autonomous circadian clocks, which orchestrate metabolic processes in a temporally appropriate manner. During the process of identifying the mechanisms by which clocks influence metabolism, molecular-based studies have revealed that metabolism should be considered an integral circadian clock component. The implications of such an interrelationship include the establishment of a vicious cycle during cardiometabolic disease states, wherein metabolism-induced perturbations in the circadian clock exacerbate metabolic dysfunction. The purpose of this review is therefore to highlight recent insights gained regarding links between cell autonomous circadian clocks and metabolism, and the implications of clock dysfunction in the pathogenesis of cardiometabolic diseases.
登录
查看更多内容
影响因子：
16.2
作者：
Cappuccio FP;D'Elia L;Strazzullo P;Miller MA
通讯作者：
Miller MA
影响因子：
15.9
作者：
BARTER, PJ;CARROLL, KF;NESTEL, PJ
通讯作者：
NESTEL, PJ
DOI：
10.1152/ajpregu.00294.2004
发表时间：
2004-11-01
影响因子：
2.8
作者：
Bodosi, B;Gardi, J;Krueger, JM
通讯作者：
Krueger, JM
影响因子：
3.2
作者：
BIANCHI, S;BIGAZZI, X;CAMPESE, VM
通讯作者：
CAMPESE, VM
影响因子：
4.8
作者：
Ando, Hitoshi;Kumazaki, Masafumi;Fujimura, Akio
通讯作者：
Fujimura, Akio