Aberrant MCT4 and GLUT1 expression is correlated with early recurrence and poor prognosis of hepatocellular carcinoma after hepatectomy.
Aberrant MCT4 and GLUT1 expression is correlated with early recurrence and poor prognosis of hepatocellular carcinoma after hepatectomy.
复制标题
MCT4和GLUT1的异常表达与肝细胞癌肝切除术后的早期复发和不良预后相关。
DOI：
10.1002/cam4.1521
复制
发表时间：
2018-11
期刊：
影响因子：
4
通讯作者：
Shi M
中科院分区：
文献类型：
--
作者：
Chen HL;OuYang HY;Le Y;Jiang P;Tang H;Yu ZS;He MK;Tang YQ;Shi M
肿瘤微环境是癌细胞生物学的关键决定因素。微环境是肿瘤细胞、基质细胞、蛋白质、细胞外基质、氧张力和调节肿瘤进展的细胞周围的pH水平的复杂混合物。本研究确定了与肝细胞癌（HCC）及HCC标本中MCT4和GLUT1表达水平相关的预后因素。在这项研究中，我们通过免疫组织化学分析了213例HCC患者组织样本中MCT4和GLUT1的表达水平，并通过定量实时PCR分析了HCC肿瘤组织和匹配的邻近非肿瘤组织中MCT4和GLUT1的表达水平。我们使用免疫反应性和其他常见的临床和病理参数对总生存期（OS）和复发时间（TTR）进行了预后分析。所有影响预后的变量进一步进行多变量分析。我们发现肿瘤组织中MCT4和GLUT1的表达水平明显高于邻近非肿瘤组织，且与肿瘤大小呈正相关。生存分析显示，MCT4或GLUT1高表达的患者OS和TTR较差。在HCC患者中，MCT4表达是OS的独立阴性预后因素（风险比[HR] = 1.617； 95%可信区间[CI] = 1.102 ~ 2.374; P = 0.014），代谢指标是OS的独立预后因素（HR = 1.617, 95% CI = 1.102 ~ 2.374, P = 0.006）和TTR （HR = 1.348, 95% CI = 1.079 ~ 1.685, P = 0.009）。有趣的是，在≤5 cm和>5 cm亚组中，肿瘤细胞代谢指标表达阳性的患者的OS明显短于肿瘤细胞代谢指标表达阴性的患者，TTR明显早于肿瘤细胞代谢指标表达阴性的患者。综上所述，利用MCT4和GLUT1的表达及其代谢参数来判断肿瘤的代谢状态，有望预测HCC患者的预后。
The tumor microenvironment is a key determinant of cancer cell biology. The microenvironment is a complex mixture of tumor cells, stromal cells, and proteins, extracellular matrix, oxygen tension, and pH levels surrounding the cells that regulate the tumor progress. This study identified the prognostic factors associated with hepatocellular carcinoma (HCC) and MCT4 and GLUT1 expression levels in HCC specimens. In this study, we analyzed MCT4 and GLUT1 expression levels in tissue samples from 213 patients with HCC by immunohistochemical analyses and in HCC tumor tissues and matched adjacent nonneoplastic tissues by quantitative real‐time PCR. We conducted a prognostic analysis of the overall survival (OS) and time to recurrence (TTR) using immunoreactivity and other common clinical and pathological parameters. All variables with prognostic impact were further analyzed by multivariate analysis. We found that MCT4 and GLUT1 expression levels were significantly higher in tumor tissues than in adjacent nontumor tissues, and they were positively correlated with tumor size. Survival analysis showed that patients with high expression levels of MCT4 or GLUT1 had a poor OS and TTR. In patients with HCC, MCT4 expression was an independent negative prognostic factor for OS (hazard ratio [HR] = 1.617; 95% confidence interval [CI] = 1.102–2.374; P = 0.014), and metabolic indicators were independent prognostic factors for OS (HR = 1.617, 95% CI = 1.102−2.374, P = 0.006) and TTR (HR = 1.348, 95% CI = 1.079−1.685, P = 0.009). Interestingly, patients with positive metabolic indicator expression in tumor cells had a significantly shorter OS and earlier TTR than those with negative metabolic indicator expression in tumor cells in the ≤5 cm and >5 cm subgroups. In summary, using the expression of MCT4 and GLUT1 and their metabolic parameters to determine the metabolic status of tumors is promising for predicting the prognosis of patients with HCC.
登录
查看更多内容
影响因子：
7.3
作者：
Gerlinger, Marco;Santos, Claudio R.;Spencer-Dene, Bradley;Martinez, Pierre;Endesfelder, David;Burrell, Rebecca A.;Vetter, Marcus;Jiang, Ming;Saunders, Rebecca E.;Kelly, Gavin;Dykema, Karl;Rioux-Leclercq, Nathalie;Stamp, Gordon;Patard, Jean Jacques;Larkin, James;Howell, Michael;Swanton, Charles
通讯作者：
Swanton, Charles
影响因子：
8
作者：
通讯作者：
--
影响因子：
6.4
作者：
Specht, Elisa;Kaemmerer, Daniel;Lupp, Amelie
通讯作者：
Lupp, Amelie
影响因子：
4.3
作者：
Alves, Venancio A.;Pinheiro, Celine;Baltazar, Fatima
通讯作者：
Baltazar, Fatima
影响因子：
3.4
作者：
Takanaga, Hitomi;Chaudhuri, Bhavna;Frommer, Wolf B.
通讯作者：
Frommer, Wolf B.