Granulocyte elastase cleaves human high molecular weight kininogen and destroys its clot-promoting activity.
Granulocyte elastase cleaves human high molecular weight kininogen and destroys its clot-promoting activity.
复制标题
DOI：
10.1084/jem.167.6.1895
复制
发表时间：
1988-06-01
影响因子：
15.3
通讯作者：
DONALDSON, V
中科院分区：
文献类型：
--
作者：
KLENIEWSKI, J;DONALDSON, V
Purified human granulocyte elastase cleaved purified human high molecular weight (HMW) kininogen into multiple low molecular weight fragments, and destroyed the clot-promoting activity of the HMW kininogen. Elastase digestion did not release kinin or destroy the bradykinin portion of the HMW kininogen molecule; kallikrein could release kinin from the elastase-induced low molecular weight digestion products of HMW kininogen. Purified alpha 1-antitrypsin prevented the destruction of the clot-promoting activity of HMW kininogen by elastase; it also delayed the clotting of normal plasma. Elastase may play a significant role in altered hemostasis as well as fibrinolysis, in areas of inflammation to which polymorphonuclear leukocytes have been attracted.
登录
查看更多内容
影响因子：
15.9
作者：
JOHNSTON, CL;HJORT, PF
通讯作者：
HJORT, PF
影响因子：
15.9
作者：
COLMAN, RW;BAGDASARIAN, A;KAPLAN, AP
通讯作者：
KAPLAN, AP
DOI：
10.1055/s-0038-1654791
发表时间：
1964-01-01
期刊：
THROMBOSIS ET DIATHESIS HAEMORRHAGICA
影响因子：
--
作者：
GANS, H
通讯作者：
GANS, H
影响因子：
2.7
作者：
IKARI, N;SUGO, T;IWANAGA, S
通讯作者：
IWANAGA, S
影响因子：
7.5
作者：
DONALDSON, VH;KLENIEWSKI, J
通讯作者：
KLENIEWSKI, J