Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.
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DOI：
10.1016/j.cell.2017.09.021
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发表时间：
2017-10-05
期刊：
影响因子：
64.5
通讯作者：
Zhang DD
中科院分区：
文献类型：
--
作者：
Stockwell BR;Friedmann Angeli JP;Bayir H;Bush AI;Conrad M;Dixon SJ;Fulda S;Gascón S;Hatzios SK;Kagan VE;Noel K;Jiang X;Linkermann A;Murphy ME;Overholtzer M;Oyagi A;Pagnussat GC;Park J;Ran Q;Rosenfeld CS;Salnikow K;Tang D;Torti FM;Torti SV;Toyokuni S;Woerpel KA;Zhang DD
铁死亡是一种受调节的细胞死亡形式，其特征是脂质氢过氧化物的铁依赖性积累达到致死水平。新出现的证据表明，铁下垂是由多不饱和脂肪酸掺入细胞膜引起的一种古老的脆弱性，并且细胞已经发展出复杂的系统，在不同的环境中利用和防御这种脆弱性。对铁下垂的敏感性与许多生物过程密切相关，包括氨基酸、铁和多不饱和脂肪酸代谢，以及谷胱甘肽、磷脂、NADPH和辅酶Q10的生物合成。在哺乳动物中，与退行性疾病（如阿尔茨海默氏病、亨廷顿氏病和帕金森病）、癌变、中风、脑出血、外伤性脑损伤、缺血再灌注损伤和肾脏变性相关的病理性细胞死亡与铁下垂有关，也与植物的热应激有关。铁下垂也可能具有肿瘤抑制功能，可用于癌症治疗。本读本回顾了铁下垂的机制，强调了与其他生物学和医学领域的联系，并推荐了研究这种新兴形式的调节细胞死亡的工具和指南。
Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation of lipid hydroperoxides to lethal levels. Emerging evidence suggests that ferroptosis represents an ancient vulnerability caused by the incorporation of polyunsaturated fatty acids into cellular membranes, and that cells have developed complex systems that exploit and defend against this vulnerability in different contexts. The sensitivity to ferroptosis is tightly linked to numerous biological processes, including amino acid, iron and polyunsaturated fatty acid metabolism, and the biosynthesis of glutathione, phospholipids, NADPH and coenzyme Q10. Ferroptosis has been implicated in the pathological cell death associated with degenerative diseases (i.e., Alzheimer's, Huntington's, and Parkinson's diseases), carcinogenesis, stroke, intracerebral hemorrhage, traumatic brain injury, ischemia-reperfusion injury, and kidney degeneration in mammals and is also implicated in heat stress in plants. Ferroptosis may also have a tumor suppressor function that could be harnessed for cancer therapy. This Primer reviews the mechanisms underlying ferroptosis, highlights connections to other areas of biology and medicine, and recommends tools and guidelines for studying this emerging form of regulated cell death.
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ACSL4 通过塑造细胞脂质成分来决定铁死亡敏感性。
影响因子：
14.8
作者：
Doll S;Proneth B;Tyurina YY;Panzilius E;Kobayashi S;Ingold I;Irmler M;Beckers J;Aichler M;Walch A;Prokisch H;Trümbach D;Mao G;Qu F;Bayir H;Füllekrug J;Scheel CH;Wurst W;Schick JA;Kagan VE;Angeli JP;Conrad M
通讯作者：
Conrad M
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
4
作者：
Dixon SJ;Winter GE;Musavi LS;Lee ED;Snijder B;Rebsamen M;Superti-Furga G;Stockwell BR
通讯作者：
Stockwell BR
DOI：
10.3174/ajnr.a5143
发表时间：
2017-06
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Chiang GC;Mao X;Kang G;Chang E;Pandya S;Vallabhajosula S;Isaacson R;Ravdin LD;Alzheimer's Disease Neuroimaging Initiative;Shungu DC
通讯作者：
Shungu DC
DOI：
10.1016/0006-291x(77)90623-4
发表时间：
1977-01-01
影响因子：
3.1
作者：
BANNAI, S;TSUKEDA, H;OKUMURA, H
通讯作者：
OKUMURA, H