Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium.
Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium.
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肠道上皮中潜在的细胞特性和微生物反应的转录程序。
DOI：
10.1038/s41575-020-00357-6
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Rawls JF
中科院分区：
文献类型：
--
作者：
Heppert JK;Davison JM;Kelly C;Mercado GP;Lickwar CR;Rawls JF
肠上皮具有独特而关键的功能，即收集膳食营养，同时作为细胞屏障将组织与肠道环境和肠道微生物生态系统分离开来。肠上皮的两个显著特征使其能够执行这些复杂的功能。首先，肠上皮内的细胞具有广泛的特化特征，包括不同的细胞类型和沿肠的明显的前后模式。其次，肠上皮细胞对肠道内环境中遇到的膳食营养物质、异种生物和微生物的动态环境非常敏感和敏感。肠上皮细胞的这些不同身份和反应性部分是通过其共享基因组中编码基因的差异转录实现的。在这里，我们回顾了小鼠和其他脊椎动物模型对肠道上皮身份和微生物反应性的转录调控机制的见解，包括DNA甲基化，染色质可及性，组蛋白修饰和转录因子。这些研究表明，大多数参与肠上皮身份的转录因子也会对微生物群的变化做出反应，这为识别潜在的综合转录调控网络带来了机遇和挑战。
The intestinal epithelium serves the unique and critical function of harvesting dietary nutrients, while simultaneously acting as a cellular barrier separating tissues from the luminal environment and gut microbial ecosystem. Two salient features of the intestinal epithelium enable it to perform these complex functions. First, cells within the intestinal epithelium achieve a wide range of specialized identities, including different cell types and distinct anterior–posterior patterning along the intestine. Second, intestinal epithelial cells are sensitive and responsive to the dynamic milieu of dietary nutrients, xenobiotics and microorganisms encountered in the intestinal luminal environment. These diverse identities and responsiveness of intestinal epithelial cells are achieved in part through the differential transcription of genes encoded in their shared genome. Here, we review insights from mice and other vertebrate models into the transcriptional regulatory mechanisms underlying intestinal epithelial identity and microbial responsiveness, including DNA methylation, chromatin accessibility, histone modifications and transcription factors. These studies are revealing that most transcription factors involved in intestinal epithelial identity also respond to changes in the microbiota, raising both opportunities and challenges to discern the underlying integrative transcriptional regulatory networks.
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影响因子：
64.8
作者：
Alenghat, Theresa;Osborne, Lisa C.;Saenz, Steven A.;Kobuley, Dmytro;Ziegler, Carly G. K.;Mullican, Shannon E.;Choi, Inchan;Grunberg, Stephanie;Sinha, Rohini;Wynosky-Dolfi, Meghan;Snyder, Annelise;Giacomin, Paul R.;Joyce, Karen L.;Hoang, Tram B.;Bewtra, Meenakshi;Brodsky, Igor E.;Sonnenberg, Gregory F.;Bushman, Frederic D.;Won, Kyoung-Jae;Lazar, Mitchell A.;Artis, David
通讯作者：
Artis, David
影响因子：
30.8
作者：
Barrett, Jeffrey C.;Clayton, David G.;Concannon, Patrick;Akolkar, Beena;Cooper, Jason D.;Erlich, Henry A.;Julier, Cecile;Morahan, Grant;Nerup, Jorn;Nierras, Concepcion;Plagnol, Vincent;Pociot, Flemming;Schuilenburg, Helen;Smyth, Deborah J.;Stevens, Helen;Todd, John A.;Walker, Neil M.;Rich, Stephen S.
通讯作者：
Rich, Stephen S.
DOI：
10.1126/science.aam9949
发表时间：
2017-08-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Byndloss MX;Olsan EE;Rivera-Chávez F;Tiffany CR;Cevallos SA;Lokken KL;Torres TP;Byndloss AJ;Faber F;Gao Y;Litvak Y;Lopez CA;Xu G;Napoli E;Giulivi C;Tsolis RM;Revzin A;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ
影响因子：
5.3
作者：
Cattin, Anne-Laure;Le Beyec, Johanne;Ribeiro, Agnes
通讯作者：
Ribeiro, Agnes
影响因子：
4.9
作者：
Ahn, Sung-Hoon;Shah, Yatrik M.;Inoue, Junko;Morimura, Keiichirou;Kim, Insook;Yim, SunHee;Lambert, Gilles;Kurotani, Reiko;Nagashima, Kunio;Gonzalez, Frank J.;Inoue, Yusuke
通讯作者：
Inoue, Yusuke