A one-pot enzymatic approach to the O-fluoroglucoside of N-methylanthranilate.
A one-pot enzymatic approach to the O-fluoroglucoside of N-methylanthranilate.
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DOI：
10.1016/j.bmc.2013.05.057
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发表时间：
2013-08-15
影响因子：
3.5
通讯作者：
Field RA
中科院分区：
文献类型：
--
作者：
Caputi L;Rejzek M;Louveau T;O'Neill EC;Hill L;Osbourn A;Field RA
In connection with prospective 18F-PET imaging studies, the potential for enzymatic synthesis of fluorine-labelled glycosides of small molecules was investigated. Approaches to the enzymatic synthesis of anomeric phosphates of d-gluco-configured fluorosugars proved ineffective. In contrast, starting in the d-galacto series and relying on the consecutive action of Escherichia coli galactokinase (GalK), galactose-1-phosphate uridylyltransferase (GalPUT), uridine-5′-diphosphogalactose 4-epimerase (GalE) and oat root glucosyltransferase (SAD10), a quick and effective synthesis of 6-deoxy-6-fluoro-d-glucosyl N-methylanthranilate ester was achieved.
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