Closed-loop stimulation of temporal cortex rescues functional networks and improves memory.
Closed-loop stimulation of temporal cortex rescues functional networks and improves memory.
复制标题
DOI：
10.1038/s41467-017-02753-0
复制
发表时间：
2018-02-06
影响因子：
16.6
通讯作者：
Kahana MJ
中科院分区：
文献类型：
--
作者：
Ezzyat Y;Wanda PA;Levy DF;Kadel A;Aka A;Pedisich I;Sperling MR;Sharan AD;Lega BC;Burks A;Gross RE;Inman CS;Jobst BC;Gorenstein MA;Davis KA;Worrell GA;Kucewicz MT;Stein JM;Gorniak R;Das SR;Rizzuto DS;Kahana MJ
内存故障令人沮丧，并且通常是无效编码的结果。改善记忆结果的一种方法是通过电刺激直接调节大脑活动。然而，之前的研究报告称，使用开环刺激时效果不一致，并且通常针对海马体和内侧颞叶。在这里，我们使用闭环系统来监测和解码人类直接大脑记录中的神经活动。我们对外侧颞叶皮层进行有针对性的刺激，并报告说这种刺激可以挽救记忆编码不良的时期。该系统还可以改善以后的回忆，表明外侧颞叶皮层是增强记忆的可靠目标。综上所述，我们的结果表明，此类系统可能为治疗记忆功能障碍提供一种治疗方法。由于无效的编码可能会导致记忆衰退，但目前尚不清楚有针对性的大脑刺激是否可以提高记忆能力。在这里，作者使用闭环系统来解码和刺激无效编码的时期，表明刺激外侧颞皮层可以增强记忆。
Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction. Memory lapses can occur due to ineffective encoding, but it is unclear if targeted brain stimulation can improve memory performance. Here, authors use a closed-loop system to decode and stimulate periods of ineffective encoding, showing that stimulation of lateral temporal cortex can enhance memory.
登录
查看更多内容
DOI：
10.1016/j.cub.2017.03.028
发表时间：
2017-05-08
期刊：
Current biology : CB
影响因子：
--
作者：
Ezzyat Y;Kragel JE;Burke JF;Levy DF;Lyalenko A;Wanda P;O'Sullivan L;Hurley KB;Busygin S;Pedisich I;Sperling MR;Worrell GA;Kucewicz MT;Davis KA;Lucas TH;Inman CS;Lega BC;Jobst BC;Sheth SA;Zaghloul K;Jutras MJ;Stein JM;Das SR;Gorniak R;Rizzuto DS;Kahana MJ
通讯作者：
Kahana MJ
影响因子：
--
作者：
Bronstein JM;Tagliati M;Alterman RL;Lozano AM;Volkmann J;Stefani A;Horak FB;Okun MS;Foote KD;Krack P;Pahwa R;Henderson JM;Hariz MI;Bakay RA;Rezai A;Marks WJ Jr;Moro E;Vitek JL;Weaver FM;Gross RE;DeLong MR
通讯作者：
DeLong MR
影响因子：
7.6
作者：
Greenberg, Benjamin D.;Malone, Donald A.;Rasmussen, Steven A.
通讯作者：
Rasmussen, Steven A.
影响因子：
5.6
作者：
Fisher, Robert;Salanova, Vicenta;Graves, Nina
通讯作者：
Graves, Nina
影响因子：
11
作者：
Boggio, P. S.;Khoury, L. P.;Fregni, F.
通讯作者：
Fregni, F.