Two kinds of transcription factors mediate chronic morphine-induced decrease in miR-105 in medial prefrontal cortex of rats.
Two kinds of transcription factors mediate chronic morphine-induced decrease in miR-105 in medial prefrontal cortex of rats.
复制标题
DOI：
10.1038/s41398-022-02222-3
复制
发表时间：
2022-10-31
影响因子：
6.8
通讯作者：
Zheng, Ping
中科院分区：
文献类型：
--
作者：
Zhang, Junfang;Guo, Xinli;Cai, Zhangyin;Pan, Yan;Yang, Hao;Fu, Yali;Cao, Zixuan;Wen, Yaxian;Chao Lei;Chu, Chenshan;Yuan, Yu;Cui, Dongyang;Gao, Pengyu;Lai, Bin;Zheng, Ping
长期服用吗啡会改变大脑不同区域的基因表达，这一影响可能有助于与成瘾行为相关的可塑性变化。这种基因表达的变化很可能是由成瘾药物诱导的基因表达程序的表观遗传重塑所介导的。我们以前的研究表明，慢性吗啡诱导的内侧前额叶皮质miR-105的减少有助于情景诱导的吗啡戒断记忆的提取。然而，慢性吗啡治疗如何降低mPFC中miR-105的表达仍不清楚。本研究表明，慢性吗啡通过两种转录因子诱导成瘾相关的mPFC miR-105的改变：第一种转录因子是由MU受体-ERK-p90RSK信号通路激活的CREB，第二种转录因子是糖皮质激素受体(GR)，它作为负转录因子，介导慢性吗啡诱导的大鼠mPFC miR-105表达下降。
Chronic morphine administration alters gene expression in different brain regions, an effect which may contribute to plastic changes associated with addictive behavior. This change in gene expression is most possibly mediated by addictive drug-induced epigenetic remodeling of gene expression programs. Our previous studies showed that chronic morphine-induced decrease of miR-105 in the medial prefrontal cortex (mPFC) contributed to context-induced retrieval of morphine withdrawal memory. However, how chronic morphine treatment decreases miR-105 in the mPFC still remains unknown. The present study shows that chronic morphine induces addiction-related change in miR-105 in the mPFC via two kinds of transcription factors: the first transcription factor is CREB activated by mu receptors-ERK-p90RSK signaling pathway and the second transcription factor is glucocorticoid receptor (GR), which as a negative transcription factor, mediates chronic morphine-induced decrease in miR-105 in the mPFC of rats.
登录
查看更多内容
影响因子：
5.3
作者：
Chen, Ming;Shao, Da;Zheng, Ping
通讯作者：
Zheng, Ping
影响因子：
2.9
作者：
MILANES, MV;PUIG, MM;VARGAS, ML
通讯作者：
VARGAS, ML
影响因子：
12.3
作者：
Piechota M;Korostynski M;Solecki W;Gieryk A;Slezak M;Bilecki W;Ziolkowska B;Kostrzewa E;Cymerman I;Swiech L;Jaworski J;Przewlocki R
通讯作者：
Przewlocki R
影响因子：
12.3
作者：
Korostynski M;Piechota M;Kaminska D;Solecki W;Przewlocki R
通讯作者：
Przewlocki R
影响因子：
4.2
作者：
Gomez-Milanes, Ivan;Almela, Pilar;Luisa Laorden, M.
通讯作者：
Luisa Laorden, M.