High level of persistence of pediatric bipolar-I disorder from childhood onto adolescent years: a four year prospective longitudinal follow-up study.
High level of persistence of pediatric bipolar-I disorder from childhood onto adolescent years: a four year prospective longitudinal follow-up study.
复制标题
从儿童期到青春期的小儿双相情感障碍的高度持久性：一项为期四年的前瞻性纵向随访研究。
DOI：
10.1016/j.jpsychires.2010.10.006
复制
发表时间：
2011-10
影响因子：
4.8
通讯作者：
Biederman J
中科院分区：
文献类型：
--
作者：
Wozniak J;Petty CR;Schreck M;Moses A;Faraone SV;Biederman J
研究从儿童期向青春期过渡的儿童双相（BP）-I障碍的纵向病程。我们对78名6-17岁的BP-I障碍青少年进行了为期4年的前瞻性随访研究，随访至青春期（13.4±3.9年）。所有受试者进行了全面评估，结构化诊断访谈，神经心理测试，心理社会，教育和治疗史评估。如果受试者在随访时符合DSM-IV BP-I障碍的完整标准，则认为BP障碍持续存在。在78名参与BP-I的青年受试者中，57名（73.1%）继续符合BP-I障碍的完整诊断标准。在非持续性病程的患者中，只有6.4%（n=5）的患者是胸腺正常的（即，综合征和症状缓解），在4年的随访，并没有接受药物治疗的障碍。其他非持续性病例继续存在阈下BP-I障碍（n=5，6.4%），符合重度抑郁症的完全（n=3，3.8%）或阈下（n=1，1.3%）标准，或情绪正常但接受了障碍治疗（n=7，9.0%）。在随访评估中，完全持续与重度抑郁症和破坏性行为障碍的发生率较高以及基线评估中兴奋剂药物的使用率较高相关。非持久性BP-I的特征还在于高水平的功能障碍和发病率。这项为期四年的随访表明，大多数BP-I障碍青少年在青春期中后期继续经历持续性障碍，其持续存在与高发病率和残疾水平相关。双相情感障碍亚综合征形式的持续存在也与功能障碍和发病率相关。
To examine the longitudinal course of pediatric bipolar (BP)-I disorder in youth transitioning from childhood into adolescence. We conducted a four-year prospective follow-up study of 78 youth with BP-I disorder 6-17 years old at ascertainment followed up into adolescent years (13.4±3.9 years). All subjects were comprehensively assessed with structured diagnostic interviews, neuropsychological testing, psychosocial, educational and treatment history assessments. BP disorder was considered persistent if subjects met full criteria for DSM-IV BP-I disorder at follow-up. Of 78 BP-I participating youth subjects, 57 (73.1%), continued to meet full diagnostic criteria for BP-I Disorder. Of those with a non-persistent course, only 6.4% (n=5) were euthymic (i.e., syndromatic and symptomatic remission) at the 4-year follow-up and were not receiving pharmacotherapy for the disorder. The other non-persistent cases either continued to have subthreshold BP-I disorder (n=5, 6.4%), met full (n=3, 3.8%) or subthreshold (n=1, 1.3%) criteria for major depression, or were euthymic but were treated for the disorder (n=7, 9.0%). Full persistence was associated with higher rates of major depression and disruptive behavior disorders at the follow-up assessment and higher use of stimulant medicines at the baseline assessment. Non-Peristent BP-I was also characterized by high levels of dysfunction and morbidity. This four-year follow-up shows that the majority of BP-I disorder youth continue to experience persistent disorder into their mid and late adolescent years and its persistence is associated with high levels of morbidity and disability. Persistence of subsyndromal forms of bipolar disorder was also associated with dysfunction and morbidity.
登录
查看更多内容
影响因子：
5.4
作者：
Findling, RL;Gracious, BL;Calabrese, JR
通讯作者：
Calabrese, JR
影响因子：
17.7
作者：
Geller, B;Craney, JL;Zimerman, B
通讯作者：
Zimerman, B
影响因子：
6.6
作者：
Biederman, J;Mick, E;Wozniak, J
通讯作者：
Wozniak, J
影响因子：
--
作者：
Chang, K;Adleman, NE;Reiss, A
通讯作者：
Reiss, A
DOI：
10.1097/01.chi.0000159948.75136.0d
发表时间：
2005-06-01
影响因子：
13.3
作者：
Chang, K;Karchemskiy, A;Reiss, A
通讯作者：
Reiss, A