InnateDB: facilitating systems-level analyses of the mammalian innate immune response.
InnateDB: facilitating systems-level analyses of the mammalian innate immune response.
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DOI：
10.1038/msb.2008.55
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发表时间：
2008
影响因子：
9.9
通讯作者：
Brinkman, Fiona S. L.
中科院分区：
文献类型：
--
作者：
Lynn, David J.;Winsor, Geoffrey L.;Chan, Calvin;Richard, Nicolas;Laird, Matthew R.;Barsky, Aaron;Gardy, Jennifer L.;Roche, Fiona M.;Chan, Timothy H. W.;Shah, Naisha;Lo, Raymond;Naseer, Misbah;Que, Jaimmie;Yau, Melissa;Acab, Michael;Tulpan, Dan;Whiteside, Matthew D.;Chikatamarla, Avinash;Mah, Bernadette;Munzner, Tamara;Hokamp, Karsten;Hancock, Robert E. W.;Brinkman, Fiona S. L.
虽然在剖析参与先天性免疫反应的信号通路方面已经取得了相当大的进展，但现在很明显，这种反应不能再用简单的线性通路来有效地考虑了。InnateDB(www.innatedb.ca)的开发是为了促进系统级的分析，这些分析将更好地洞察支配先天性免疫反应的复杂的路径和相互作用网络。InnateDB是一个公开可用的、人工管理的、关于人类和老鼠分子的综合生物学数据库，通过实验验证了与先天性免疫有关的相互作用和途径，并对更广泛的人类和老鼠相互作用进行了集中注释。到目前为止，通过对1000多篇出版物的审查，3500多项与先天免疫相关的相互作用已被上下文注释。InnateDB集成了新的生物信息学资源，包括网络可视化软件、途径分析、同源相互作用网络构建以及在直观显示的分子相互作用网络和途径背景中覆盖用户提供的基因表达数据的能力，这将使没有计算背景的生物学家能够以更面向系统的方式探索他们的数据。
Although considerable progress has been made in dissecting the signaling pathways involved in the innate immune response, it is now apparent that this response can no longer be productively thought of in terms of simple linear pathways. InnateDB (www.innatedb.ca) has been developed to facilitate systems-level analyses that will provide better insight into the complex networks of pathways and interactions that govern the innate immune response. InnateDB is a publicly available, manually curated, integrative biology database of the human and mouse molecules, experimentally verified interactions and pathways involved in innate immunity, along with centralized annotation on the broader human and mouse interactomes. To date, more than 3500 innate immunity-relevant interactions have been contextually annotated through the review of 1000 plus publications. Integrated into InnateDB are novel bioinformatics resources, including network visualization software, pathway analysis, orthologous interaction network construction and the ability to overlay user-supplied gene expression data in an intuitively displayed molecular interaction network and pathway context, which will enable biologists without a computational background to explore their data in a more systems-oriented manner.
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影响因子：
14.9
作者：
UniProt Consortium
通讯作者：
UniProt Consortium
影响因子：
14.9
作者：
Hokamp, K;Roche, FM;Brinkman, FSL
通讯作者：
Brinkman, FSL
影响因子：
14.9
作者：
Goffard N;Weiller G
通讯作者：
Weiller G
影响因子：
14.9
作者：
Bruford, Elspeth A.;Lush, Michael J.;Wright, Mathew W.;Sneddon, Tam P.;Povey, Sue;Birney, Ewan
通讯作者：
Birney, Ewan
影响因子：
14.9
作者：
Kanehisa M;Araki M;Goto S;Hattori M;Hirakawa M;Itoh M;Katayama T;Kawashima S;Okuda S;Tokimatsu T;Yamanishi Y
通讯作者：
Yamanishi Y