Quantitative aspects of corticocortical connections: a tracer study in the mouse.
Quantitative aspects of corticocortical connections: a tracer study in the mouse.
复制标题
皮质连接的定量方面：小鼠示踪研究。
作者：
A. Schüz;D. Chaimow;Daniel Liewald;Monika Dortenman
这项研究提供了与大脑皮质活动传播的模型和模拟相关的神经解剖学数据。我们将顺行示踪剂生物素化葡聚糖胺小剂量注射到小鼠大脑皮质的不同区域(每只动物1只)。对皮质表面进行了二维重建，显示了终末野的分布、大小和密度。在注射半球内，末端野的最大部分总是围绕注射部位并延伸到邻近区域。平均而言，来自注射部位的轴突(包含数千个神经元)散布到比注射部位大180倍的区域。远端视野内染色纤维密度可达25m/mm~3左右。来自单个注入点的总末端场的一半以上由密度为3或4m/mm3的弱突起组成。进入一个单独的远端视野的主轴突数在14到约890之间。通过间接论证，我们估计靠近注射部位的染色纤维密度是标记最密集的远端视野的3-6倍。除了对侧大脑半球的对称性投射外，还发现了非同源的胼胝体投射。
This study provides neuroanatomical data relevant to models and simulations of the propagation of activity over the cortex. We administered small injections of the anterograde tracer biotinylated dextran amine to various regions of the mouse cortex (1 per animal). Two-dimensional reconstructions of the cortical surface were made, showing the distribution, size, and density of the terminal fields. Within the injected hemisphere, the largest part of the terminal field always surrounded the injection site and extended over neighboring areas. On average, axons from injection sites of <or=0.1 mm2 (containing several thousand neurons) diverged onto a region about 180 times larger than the injection site. The density of stained fibers in distant terminal fields could reach about 25 m/mm3. More than half of the total terminal field from an individual injection site consisted of weak projections with densities of 3 or 4 m/mm3. The number of main axons entering an individual distant terminal field ranged between 14 and about 890. By indirect arguments we estimate that the density of stained fibers close to the injection site is 3-6 times that in the most densely labeled distant terminal fields. In addition to symmetric projections to the opposite hemisphere, nonhomotopic callosal projections were found.
影响因子：
3.7
作者：
LUND, JS;YOSHIOKA, T;LEVITT, JB
通讯作者：
LEVITT, JB
猫感觉运动皮层皮质-皮质中继的形态特征。
DOI：
10.1093/cercor/7.2.100
发表时间：
1997
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Porter,LL
通讯作者：
Porter,LL
影响因子：
2.5
作者：
COWAN, RL;WILSON, CJ
通讯作者：
WILSON, CJ