Associations between consumption of three types of beverages and risk of cardiometabolic multimorbidity in UK Biobank participants: a prospective cohort study.
Associations between consumption of three types of beverages and risk of cardiometabolic multimorbidity in UK Biobank participants: a prospective cohort study.
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英国生物银行参与者饮用三种饮料与心脏代谢多种疾病风险之间的关联：一项前瞻性队列研究
DOI：
10.1186/s12916-022-02456-4
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发表时间：
2022-08-18
期刊：
影响因子：
9.3
通讯作者：
Zhang, Guogang
中科院分区：
文献类型：
--
作者：
Luo, Yi;He, Lingfang;Ma, Tianqi;Li, Jinchen;Bai, Yongping;Cheng, Xunjie;Zhang, Guogang
关键词：
背景尽管饮料与单一心脏代谢疾病之间的关联已得到充分研究，但它们在从单一心脏代谢疾病状态到心脏代谢多病（CMM）状态的疾病进展中的作用仍不清楚。这项研究检查了三种类型的饮料：含糖饮料 (SSB)、人工甜味剂饮料 (ASB) 和纯果汁/蔬菜汁与单一心脏代谢疾病患者 CMM 发病率之间的关联。方法我们的分析包括来自英国生物银行的 37,994 名参与者，他们至少完成了一份饮食调查问卷，并且在招募时仅被诊断患有一种心脏代谢疾病。使用竞争风险模型来检查三种饮料与 CMM 发病率之间的关联。我们对患有任何单一心脏代谢疾病的患者和患有特定心脏代谢疾病的患者进行了分析。结果在中位随访 9.1 年（四分位距 [IQR] 9.0-9.8）期间，共有 6399 名参与者出现了 CMM。 SSB 和 ASB 的摄入量（每天 > 1 份）与较高的 CMM 风险相关（SSB：风险比 [HR] 1.19，95% 置信区间 [95% CI] 1.08–1.31；ASB：HR 1.15，95% CI 1.04–1.27）。纯果汁/蔬菜汁的摄入量与 CMM 的发病率呈负相关（每天 0-1 份：HR 0.90，95% CI 0.85-0.94；每天 >1 份：HR 0.90，95% CI 0.81-0.99）。然而，在校正多重测试后，大量饮用纯果汁/蔬菜汁（每天 > 1 份）的关联并不具有统计学意义。在对特定心脏代谢疾病患者的分析中，在高血压患者中观察到 SSB 摄入量呈正相关，而在心血管疾病患者（冠心病或中风）和高血压患者中，与纯果汁/蔬菜汁摄入量呈负相关。 结论 对于单一心脏代谢疾病患者，每天摄入超过 1 份 SSB 和 ASB 与较高的 CMM 风险相关。相比之下，纯果汁/蔬菜汁的摄入量与 CMM 风险呈负相关。我们的研究结果强调需要限制 SSB 和 ASB 在患有单一心脏代谢疾病的患者中的使用。
BackgroundAlthough the association between beverages and a single cardiometabolic disease has been well studied, their role in disease progression from the single cardiometabolic disease state to cardiometabolic multimorbidity (CMM) state remains unclear. This study examined the associations between three types of beverages: sugar-sweetened beverages (SSBs), artificially sweetened beverages (ASBs), and pure fruit/vegetable juices, and the incidence of CMM in patients with a single cardiometabolic disease.MethodsOur analysis included 37,994 participants from the UK Biobank who completed at least one dietary questionnaire and were diagnosed with only one cardiometabolic disease at the time of recruitment. Competing risk models were used to examine the association between the three types of beverages and incidence of CMM. We conducted analysis both in patients with any single cardiometabolic disease and in patients with specific cardiometabolic disease.ResultsDuring a median follow-up of 9.1 years (interquartile range [IQR] 9.0–9.8), a total of 6399 participants developed CMM. The consumption of SSBs and ASBs (>1 serving per day) was associated with a higher risk of CMM (SSBs: hazard ratio [HR] 1.19, 95% confidence interval [95% CI] 1.08–1.31; ASBs: HR 1.15, 95% CI 1.04–1.27). Intake of pure fruit/vegetable juices was inversely associated with the incidence of CMM (0–1 serving per day: HR 0.90, 95% CI 0.85–0.94; >1 serving per day: HR 0.90, 95% CI 0.81–0.99). However, the association of the high-level consumption of pure fruit/vegetable juices (>1 serving per day) was not statistically significant after correcting for multiple testing. In the analysis of patients with specific cardiometabolic diseases, positive associations were observed in patients with hypertension for SSBs consumption, while inverse associations persisted in patients with cardiovascular disease (coronary heart disease or stroke) and in hypertensive patients for pure fruit/vegetable juice consumption.ConclusionsConsuming >1 serving of SSBs and ASBs per day was associated with a higher risk of CMM in patients with a single cardiometabolic disease. In contrast, intake of pure fruit/vegetable juices was inversely associated with the risk of CMM. Our findings highlight the need to limit the use of SSBs and ASBs in patients with a single cardiometabolic disease.
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影响因子：
4.8
作者：
Gardener H;Moon YP;Rundek T;Elkind MSV;Sacco RL
通讯作者：
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作者：
Geidl-Flueck, Bettina;Hochuli, Michel;Gerber, Philipp A.
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5.5
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影响因子：
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估计能量摄入所需的24小时饮食召回数量。
影响因子：
5.6
作者：
Ma, Yunsheng;Olendzki, Barbara C.;Pagoto, Sherry L.;Hurley, Thomas G.;Magner, Robert P.;Ockene, Ira S.;Schneider, Kristin L.;Merriam, Philip A.;Hebert, James R.
通讯作者：
Hebert, James R.