Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster.
Effects of age, sex, and genotype on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster.
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DOI：
10.1111/acel.12215
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发表时间：
2014-08
期刊：
影响因子：
7.8
通讯作者：
Promislow DE
中科院分区：
文献类型：
--
作者：
Hoffman JM;Soltow QA;Li S;Sidik A;Jones DP;Promislow DE
Researchers have used whole-genome sequencing and gene expression profiling to identify genes associated with age, in the hope of understanding the underlying mechanisms of senescence. But there is a substantial gap from variation in gene sequences and expression levels to variation in age or life expectancy. In an attempt to bridge this gap, here we describe the effects of age, sex, genotype, and their interactions on high-sensitivity metabolomic profiles in the fruit fly, Drosophila melanogaster. Among the 6800 features analyzed, we found that over one-quarter of all metabolites were significantly associated with age, sex, genotype, or their interactions, and multivariate analysis shows that individual metabolomic profiles are highly predictive of these traits. Using a metabolomic equivalent of gene set enrichment analysis, we identified numerous metabolic pathways that were enriched among metabolites associated with age, sex, and genotype, including pathways involving sugar and glycerophospholipid metabolism, neurotransmitters, amino acids, and the carnitine shuttle. Our results suggest that high-sensitivity metabolomic studies have excellent potential not only to reveal mechanisms that lead to senescence, but also to help us understand differences in patterns of aging among genotypes and between males and females.
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影响因子：
30.8
作者：
Kettunen, Johannes;Tukiainen, Taru;Sarin, Antti-Pekka;Ortega-Alonso, Alfredo;Tikkanen, Emmi;Lyytikainen, Leo-Pekka;Kangas, Antti J.;Soininen, Pasi;Wuertz, Peter;Silander, Kaisa;Dick, Danielle M.;Rose, Richard J.;Savolainen, Markku J.;Viikari, Jorma;Kahonen, Mika;Lehtimaki, Terho;Pietilainen, Kirsi H.;Inouye, Michael;McCarthy, Mark I.;Jula, Antti;Eriksson, Johan;Raitakari, Olli T.;Salomaa, Veikko;Kaprio, Jaakko;Jarvelin, Marjo-Riitta;Peltonen, Leena;Perola, Markus;Freimer, Nelson B.;Ala-Korpela, Mika;Palotie, Aarno;Ripatti, Samuli
通讯作者：
Ripatti, Samuli
影响因子：
4.1
作者：
HOFFMANN, AA;PARSONS, PA
通讯作者：
PARSONS, PA
影响因子：
9.8
作者：
Coburn C;Allman E;Mahanti P;Benedetto A;Cabreiro F;Pincus Z;Matthijssens F;Araiz C;Mandel A;Vlachos M;Edwards SA;Fischer G;Davidson A;Pryor RE;Stevens A;Slack FJ;Tavernarakis N;Braeckman BP;Schroeder FC;Nehrke K;Gems D
通讯作者：
Gems D
影响因子：
3.7
作者：
Koštál V;Korbelová J;Rozsypal J;Zahradníčková H;Cimlová J;Tomčala A;Šimek P
通讯作者：
Šimek P
影响因子：
5.4
作者：
Fuchs S;Bundy JG;Davies SK;Viney JM;Swire JS;Leroi AM
通讯作者：
Leroi AM