Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease.
Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease.
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DOI：
10.1002/ibd.20480
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发表时间：
2008-07
影响因子：
4.9
通讯作者：
Dwinell, Michael B.
中科院分区：
文献类型：
--
作者：
Zimmerman, Noah P.;Vongsa, Rebecca A.;Wendt, Michael K.;Dwinell, Michael B.
趋化因子是一类具有化学吸引力的小细胞因子，其受体在免疫应答和体内平衡的调节中起着不可或缺的作用。趋化因子吸引特定免疫细胞群体的能力使其与其他化学引诱物区分开来。在胃肠道粘膜内产生的趋化因子是指导健康、炎症性肠病和结肠癌进展中生理和病理生理炎症之间平衡的关键参与者。除了趋化因子在免疫细胞向肠粘膜的定向运输中的充分表征的作用之外，上皮细胞上的趋化因子受体的表达使它们成为趋化因子信号传导网络的积极参与者。最近的研究表明，趋化因子和趋化因子受体在上皮屏障的修复和维护中起着重要作用，并在限制结肠癌转移中起着复杂的作用。对屏障缺陷和炎症以及炎症性肠病中随后的癌症进展之间的关联的认识增加，从而暗示趋化因子是粘膜稳态和疾病发病机制的关键调节因子。
Chemokines, a large family of small chemoattractive cytokines, and their receptors play an integral role in the regulation of the immune response and homeostasis. The ability of chemokines to attract specific populations of immune cells sets them apart from other chemoattractants. Chemokines produced within the gastrointestinal mucosa, are critical players in directing the balance between physiological and pathophysiological inflammation in health, inflammatory bowel disease and the progression to colon cancer. In addition to the well-characterized role of chemokines in directed trafficking of immune cells to the gut mucosa, the expression of chemokine receptors on the cells of the epithelium makes them active participants in the chemokine signaling network. Recent findings demonstrate an important role for chemokines and chemokine receptors in epithelial barrier repair and maintenance as well as an intricate involvement in limiting metastasis of colonic carcinoma. Increased recognition of the association between barrier defects and inflammation and the subsequent progression to cancer in inflammatory bowel disease thus implicates chemokines as key regulators of mucosal homeostasis and disease pathogenesis.
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