Metabolomics to reveal biomarkers and pathways of preterm birth: a systematic review and epidemiologic perspective.
Metabolomics to reveal biomarkers and pathways of preterm birth: a systematic review and epidemiologic perspective.
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DOI：
10.1007/s11306-019-1587-1
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发表时间：
2019-09-10
期刊：
影响因子：
--
通讯作者：
Sumner S
中科院分区：
文献类型：
--
作者：
Carter RA;Pan K;Harville EW;McRitchie S;Sumner S
早产是婴儿发病率和死亡率的主要原因，其大多数已知的风险因素是不可改变的。先进的分子技术正越来越多地应用于确定疾病发展和进展中重要的生物标志物和途径。我们回顾了文献的状态，并从流行病学的角度进行评估。于2019年1月31日检索了PubMed、Embase、CINAHL和科克伦中心，以查找1998年之后发表的利用非靶向代谢组学方法识别早产标志物的原始文章。合格的手稿经过同行评审，包括来自人类研究的母体组织非靶向代谢组学分析的原始数据，这些研究旨在确定早产的机制和预测因素。在2，823个结果中，14篇文章符合纳入要求。在研究设计、结局定义、生物标本类型或纳入协变量和混杂因素方面几乎没有一致性，在本综述中几乎没有发现与代谢物的一致性相关性。迄今为止，关于早产代谢组学预测因子的研究在方法学和代谢产物鉴定方面都高度异质。迫切需要在明确定义的人群中进行更大规模的研究，以确定预测早产的生物标志物，并揭示制定干预策略的机制和目标。
Most known risk factors for preterm birth, a leading cause of infant morbidity and mortality, are not modifiable. Advanced molecular techniques are increasingly being applied to identify biomarkers and pathways important in disease development and progression. We review the state of the literature and assess it from an epidemiologic perspective. PubMed, Embase, CINAHL, and Cochrane Central were searched on January 31, 2019 for original articles published after 1998 that utilized an untargeted metabolomic approach to identify markers of preterm birth. Eligible manuscripts were peer-reviewed and included original data from untargeted metabolomics analyses of maternal tissue derived from human studies designed to determine mechanisms and predictors of preterm birth. Of 2,823 results, 14 articles met the inclusion requirements. There was little consistency in study design, outcome definition, type of biospecimen, or the inclusion of covariates and confounding factors, and few consistent associations with metabolites were identified in this review. Studies to date on metabolomic predictors of preterm birth are highly heterogeneous in both methodology and resulting metabolite identification. There is an urgent need for larger studies in well-defined populations, to determine biomarkers predictive of preterm birth, and to reveal mechanisms and targets for development of intervention strategies.
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早产的妇女具有独特的宫颈阴道代谢组。
影响因子：
9.8
作者：
Ghartey J;Bastek JA;Brown AG;Anglim L;Elovitz MA
通讯作者：
Elovitz MA
影响因子：
4.6
作者：
Fotiou M;Fotakis C;Tsakoumaki F;Athanasiadou E;Kyrkou C;Dimitropoulou A;Tsiaka T;Chatziioannou AC;Sarafidis K;Menexes G;Theodoridis G;Biliaderis CG;Zoumpoulakis P;Athanasiadis AP;Michaelidou AM
通讯作者：
Michaelidou AM
影响因子：
3.7
作者：
Baraldi E;Giordano G;Stocchero M;Moschino L;Zaramella P;Tran MR;Carraro S;Romero R;Gervasi MT
通讯作者：
Gervasi MT
影响因子：
7.1
作者：
Hassan, S. S.;Romero, R.;Creasy, G. W.
通讯作者：
Creasy, G. W.
影响因子：
3.6
作者：
Beger, Richard D.;Dunn, Warwick;Schmidt, Michael A.;Gross, Steven S.;Kirwan, Jennifer A.;Cascante, Marta;Brennan, Lorraine;Wishart, David S.;Oresic, Matej;Hankemeier, Thomas;Broadhurst, David I.;Lane, Andrew N.;Suhre, Karsten;Kastenmueller, Gabi;Sumner, Susan J.;Thiele, Ines;Fiehn, Oliver;Kaddurah-Daouk, Rima
通讯作者：
Kaddurah-Daouk, Rima