Phylogenomic analysis of the understudied Neisseriaceae species reveals a poly- and paraphyletic Kingella genus.
Phylogenomic analysis of the understudied Neisseriaceae species reveals a poly- and paraphyletic Kingella genus.
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DOI：
10.1128/spectrum.03123-23
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发表时间：
2023-12-12
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
奈瑟菌科的分类学分类和系统发育分析集中于病原体脑膜炎奈瑟菌和淋病奈瑟菌。人们对共生奈瑟菌属物种和其他奈瑟菌科属的关系知之甚少，这增加了该科的系统发育可能与当前分类学不一致的可能性。在这项研究中，我们使用现有的核苷酸序列和系统发育方法来评估金氏菌属及其亲属。我们发现该属既是并系系又是多系系。与其他金氏菌属物种相比，金氏菌与杆菌状奈瑟菌的关系更为密切。 Alysiella 和 Simonsiella 属在 Kingella 属内形成一个独特的分支，与病原体 K. kingae 和 K. negevensis 密切相关。我们发现 Conchiformibius、Alysiella、Simonsiella 和 Kingella 之间存在系统发育关系，我们将其命名为 CASK 分支。最后，我们定义了将 CASK 分支的每个属彼此区分以及与奈瑟菌科其他属区分的基因集。由于奈瑟菌科物种之间的高重组率，了解奈瑟菌科物种之间的进化关系一直是细菌系统学中的一个持续挑战。之前对该家族的研究主要集中在脑膜炎奈瑟菌和淋病奈瑟菌。然而，之前未被充分研究的奈瑟菌科物种正在获得新的关注，金氏金氏菌现在被认为是一种常见的人类病原体，而阿利西菌和西蒙西菌作为多细胞生物在细菌世界中是独一无二的。更好地了解奈瑟菌科的基因组进化可以识别构成该科显着多样性的特定基因和性状。
Taxonomic classification and phylogenetic analysis of the Neisseriaceae family have focused on the pathogens Neisseria meningitidis and Neisseria gonorrhoeae. Less is known about the relationships of commensal Neisseria species and other Neisseriaceae genera, raising the possibility that the phylogeny of this family may not agree with current taxonomy. In this study, we used available nucleotide sequences and a phylogenetic approach to assess the Kingella genus and its relatives. We found that this genus is both paraphyletic and polyphyletic. Kingella potus is more closely related to Neisseria bacilliformis than to other Kingella species. The Alysiella and Simonsiella genera form a distinct clade within the Kingella genus that is closely related to the pathogens K. kingae and K. negevensis. We find a phylogenetic relationship between Conchiformibius, Alysiella, Simonsiella, and Kingella, which we name the CASK clade. Finally, we define the gene sets that differentiate each genus of the CASK clade from one another and from the rest of the Neisseriaceae family. Understanding the evolutionary relationships between the species in the Neisseriaceae family has been a persistent challenge in bacterial systematics due to high recombination rates in these species. Previous studies of this family have focused on Neisseria meningitidis and N. gonorrhoeae. However, previously understudied Neisseriaceae species are gaining new attention, with Kingella kingae now recognized as a common human pathogen and with Alysiella and Simonsiella being unique in the bacterial world as multicellular organisms. A better understanding of the genomic evolution of the Neisseriaceae can lead to the identification of specific genes and traits that underlie the remarkable diversity of this family.
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DOI：
10.1099/ijsem.0.004150
发表时间：
2020-01-01
影响因子：
2.8
作者：
Bernard, Kathryn A.;Burdz, Tamara;Bernier, Anne-Marie
通讯作者：
Bernier, Anne-Marie
DOI：
10.1099/00207713-43-3-490
发表时间：
1993-07-01
期刊：
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY
影响因子：
--
作者：
DEWHIRST, FE;CHEN, CKC;ZAMBON, JJ
通讯作者：
ZAMBON, JJ
DOI：
10.1099/ijsem.0.001957
发表时间：
2017-07-01
影响因子：
2.8
作者：
El Houmami, Nawal;Bakour, Sofiane;Fournier, Pierre-Edouard
通讯作者：
Fournier, Pierre-Edouard
影响因子：
--
作者：
Auch AF;von Jan M;Klenk HP;Göker M
通讯作者：
Göker M
DOI：
10.1099/ijs.0.01952-0
发表时间：
2002-07-01
影响因子：
2.8
作者：
Hedlund, BP;Staley, JT
通讯作者：
Staley, JT