Chemical and pharmacological studies of saponins with a focus on American ginseng.
Chemical and pharmacological studies of saponins with a focus on American ginseng.
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DOI：
10.5142/jgr.2010.34.3.160
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发表时间：
2010-09-01
影响因子：
6.3
通讯作者：
Qi LW
中科院分区：
文献类型：
--
作者：
Yuan CS;Wang CZ;Wicks SM;Qi LW
亚洲人参（Panax ginseng）和西洋参（Panax quinquefolius L.）是两种最被认可的人参植物。人们认为，人参皂苷是这两种人参的主要活性成分。虽然西洋参没有像亚洲人参那样被广泛研究，但它是美国最畅销的草药之一，近年来引起了科学家们越来越多的关注。本文在简要介绍了西洋参的分布和栽培情况后，讨论了两种人参中皂苷的化学分析，即它们的异同。在此基础上，综述了其药理作用，包括对心血管系统、免疫系统、中枢神经系统的作用以及抗糖尿病和抗癌作用。这些调查主要来源于西洋参研究。我们还讨论了证据表明，人参皂苷的化学修饰将是一个有价值的方法来开发新的药物发现化合物。
Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L.) are the two most recognized ginseng botanicals. It is believed that the ginseng saponins called ginsenosides are the major active constituents in both ginsengs. Although American ginseng is not as extensively studied as Asian ginseng, it is one of the best selling herbs in the U.S., and has garnered increasing attention from scientists in recent years. In this article, after a brief introduction of the distribution and cultivation of American ginseng, we discuss chemical analysis of saponins from these two ginsengs, i.e., their similarities and differences. Subsequently, we review pharmacological effects of the saponins, including the effects on the cardiovascular system, immune system, and central nervous system as well as the antidiabetes and anti-cancer effects. These investigations were mainly derived from American ginseng studies. We also discuss evidence suggesting that chemical modifications of ginseng saponins would be a valuable approach to develop novel compounds in drug discovery.
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影响因子：
5
作者：
Kim, Sun Mi;Lee, So Yong;Hong, Jin Tae
通讯作者：
Hong, Jin Tae
影响因子：
5.8
作者：
Kim, So-Young;Kim, Dong-Hyun;Kim, Hee-Sun
通讯作者：
Kim, Hee-Sun
DOI：
10.1016/s0378-4347(96)00304-0
发表时间：
1997-02-21
影响因子：
3
作者：
Cui, JF;Bjorkhem, I;Eneroth, P
通讯作者：
Eneroth, P
影响因子：
6.1
作者：
Corbit, R;Ebbs, S;Murphy, LL
通讯作者：
Murphy, LL
影响因子：
6.1
作者：
Lim, W;Mudge, KW;Vermeylen, F
通讯作者：
Vermeylen, F