Grape Seed Proanthocyanidins play the roles of radioprotection on Normal Lung and radiosensitization on Lung Cancer via differential regulation of the MAPK Signaling Pathway.
Grape Seed Proanthocyanidins play the roles of radioprotection on Normal Lung and radiosensitization on Lung Cancer via differential regulation of the MAPK Signaling Pathway.
复制标题
葡萄籽原花青素通过差异调节 MAPK 信号通路发挥正常肺的辐射防护作用和肺癌的放射增敏作用
DOI：
10.7150/jca.49987
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
Gao F
中科院分区：
文献类型：
--
作者：
Xu Y;Huang Y;Chen Y;Cao K;Liu Z;Wan Z;Liao Z;Li B;Cui J;Yang Y;Xu X;Cai J;Gao F
放射性肺损伤（RILI）是肺癌放疗常见的严重并发症和剂量限制因素。本研究旨在探讨葡萄籽原花青素（GSP）对正常肺的辐射防护作用以及对肺癌的辐射增敏作用。在体外，我们证明了GSP对正常肺泡上皮细胞（MLE-12和BEAS/2B）的放射保护作用以及对肺癌细胞（LLC和A549）的放射增敏作用。在体内，我们在荷瘤小鼠中证实了这种双向效应。结果表明，GSP能抑制肿瘤生长，并与放疗对肺癌有协同杀伤作用。同时，GSP降低了辐射对正常肺组织的损伤。GSP对正常肺和肺癌MAPK信号通路的差异调控的双向效应。此外，GSP调节正常肺和肺癌细胞因子IL-6和IFN-γ的分泌以及p53和Ki67的表达。我们的研究结果表明，GSP有望成为肺癌放疗患者理想的放射防护药物。
Radiation-induced lung injury (RILI) is a common serious complication and dose-limiting factor caused by radiotherapy for lung cancer. This study was to investigate radioprotective effects of grape seed proanthocyanidins (GSP) on normal lung as well as radiosensitizing effects on lung cancer. In vitro, we demonstrated radioprotective effects of GSP on normal alveolar epithelial cells (MLE-12 and BEAS/2B) and radiosensitizing effects on lung cancer cells (LLC and A549). In vivo, we confirmed these two-way effects in tumor-bearing mice. The results showed that GSP inhibited tumor growth, and played a synergistic killing effect with radiotherapy on lung cancer. Meanwhile, GSP reduced radiation damage to normal lung tissues. The two-way effects related to the differential regulation of the MAPK signaling pathway by GSP on normal lung and lung cancer. Moreover, GSP regulated secretion of cytokines IL-6 and IFN-γ and expression of p53 and Ki67 on normal lung and lung cancer. Our findings suggest that GSP is expected to be an ideal radioprotective drug for lung cancer patients who are treated with radiotherapy.
登录
查看更多内容
DOI：
10.1186/1756-9966-29-145
发表时间：
2010-11-09
期刊：
Journal of experimental & clinical cancer research : CR
影响因子：
--
作者：
Chang C;Zhu YQ;Mei JJ;Liu SQ;Luo J
通讯作者：
Luo J
小檗碱通过细胞间粘附分子-1和转化生长因子-β-1对肺癌患者放射性肺损伤的保护作用
影响因子：
8.4
作者：
Liu, Yunfang;Yu, Huiming;Zhao, Yuxia
通讯作者：
Zhao, Yuxia
影响因子：
3.9
作者：
Lee, Myung-hee;Nam, Tae Gyu;Lim, Tae-Gyu
通讯作者：
Lim, Tae-Gyu
影响因子：
11.2
作者：
Li, Shangze;Fong, Ka-wing;Yu, Jindan
通讯作者：
Yu, Jindan
影响因子：
5.5
作者：
Abbasi, Bilal Haider;Nazir, Munazza;Hano, Christophe
通讯作者：
Hano, Christophe