Fabrication of magneto-controlled moveable architecture to develop reusable electrochemical biosensors.

Fabrication of magneto-controlled moveable architecture to develop reusable electrochemical biosensors.
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制造磁控可移动结构以开发可重复使用的电化学生物传感器

DOI:
10.1038/srep04169
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发表时间:
2014-02-25
期刊:
影响因子:
4.6
通讯作者:
Li G
Li G
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Zhu X;Feng C;Ye Z;Chen Y;Li G

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电化学生物传感器的研究已经深入了几十年。已经开发了许多传感概念和相关的接口架构。然而,所有这样的体系结构都有一个权衡:简单的体系结构倾向于可用性,而复杂的体系结构倾向于更好的性能。为了克服这一问题,我们提出了一种新的概念,即引入磁控可移动结构(MCMA)来代替传统的表面固定结构。本研究以人乳腺癌细胞为模型。结果表明,该方法可实现100 ~ 1 × 106个细胞的检测范围。整个检测周期,包括测量和再生,可以在2分钟内完成。因此,在单个生物传感器中可以实现可用性和优异的性能。
Electrochemical biosensors have been studied intensively for several decades. Numerous sensing concepts and related interface architectures have been developed. However, all such architectures suffer a trade-off: simple architectures favour usability, whereas complex architectures favour better performance. To overcome this problem, we propose a novel concept by introducing a magneto-controlled moveable architecture (MCMA) instead of the conventional surface-fixed architecture. As a model, human breast cancer cells were used in this study. The results showed that a detection range from 100 to 1 × 106cells could be achieved. Moreover, the whole detection cycle, including the measurement and the regeneration, could be completed in only 2 min. Thus, usability and excellent performance can be achieved in a single biosensor.
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