Multi-dimensional MR spectroscopy: towards a better understanding of hepatic encephalopathy.
Multi-dimensional MR spectroscopy: towards a better understanding of hepatic encephalopathy.
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DOI：
10.1007/s11011-011-9250-1
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发表时间：
2011-09
影响因子：
3.6
通讯作者：
Thomas, M. Albert
中科院分区：
文献类型：
--
作者：
Sarma, Manoj K.;Huda, Amir;Nagarajan, Rajakumar;Hinkin, Charles H.;Wilson, Neil;Gupta, Rakesh K.;Frias-Martinez, Enrique;Sayre, James;Guze, Barry;Han, Steven-Huy;Thomas, M. Albert
肝性脑病（HE）通常通过神经心理学（NP）测试进行诊断。本研究的目的是量化大脑代谢物，分离谷氨酸（Glu）从谷氨酰胺（Gln）在轻微肝性脑病（MHE）患者以及健康受试者使用先验知识拟合（ProFit）算法的二维（2D）局部相关光谱（L-COSY）在两个不同的MR扫描仪上获得的数据，并与神经心理学（NP）测试的代谢物的变化。我们使用GE 1.5T Signa MR扫描仪研究了14例MHE患者和18例健康对照者。另一组16名MHE患者和18名健康对照者使用Siemens 1.5T Avanto MR扫描仪进行研究。L-COSY使用以下参数：TR/TE=2s/30 ms，3×3× 3cm 3体素尺寸，96个Δt1增量，每个Δt1 8个平均值。使用ProFit算法，我们能够在内侧额叶白色/灰质的GE 1.5T数据上区分Gln和Glu。与健康对照组相比，HE患者的肌醇（mI）、谷氨酸（Glu）、总胆碱、鲨肌醇（sI）、磷酸乙醇胺（PE）和总N-乙酰天冬氨酸（NAA）的比率显示出统计学显著下降，而谷氨酰胺（Gln）的比率显著增加。在ProFit量化Siemens 1.5 T数据中，在额叶和枕顶白色/灰色区域中观察到类似趋势。在NP领域得分中，运动功能、认知速度、执行功能和整体得分差异有统计学意义。还观察到各种NP结构域和代谢物比率之间的良好相关性。基于ProFit的脑代谢物定量增强了对MHE当前假设的理解和基础。
Hepatic encephalopathy (HE) is normally diagnosed by neuropsychological (NP) tests. The goals of this study were to quantify cerebral metabolites, separate glutamate (Glu) from glutamine (Gln) in patients with minimal hepatic encephalopathy (MHE) as well as healthy subjects using the prior-knowledge fitting (ProFit) algorithm on data acquired by two-dimensional (2D) localized correlated spectroscopic (L-COSY) on two different MR scanners, and to correlate the metabolite changes with neuropsychological (NP) tests. We studied 14 MHE patients and 18 healthy controls using a GE 1.5T Signa MR scanner. Another group of 16 MHE patients and 18 healthy controls were studied using a Siemens 1.5T Avanto MR scanner. The following parameters were used for L-COSY: TR/TE=2s/30ms, 3×3×3cm3 voxel size, 96 Δt1 increments with 8 averages per Δt1. Using the ProFit algorithm, we were able to differentiate Gln from Glu on the GE 1.5T data in the medial frontal white/gray matter. The ratios of myo-inositol (mI), Glu, total choline, scyllo-inositol (sI), phosphoethanolamine (PE), and total N-acetyl aspartate (NAA) showed statistically significant decline in HE patients compared to healthy controls, while the ratio of Gln was significantly increased. Similar trend was seen in the ProFit quantified Siemens 1.5T data in the frontal and occipito-parietal white/gray regions. Among the NP domain scores, motor function, cognitive speed, executive function and the global scores showed significant differences. Excellent correlations between various NP domains and metabolite ratios were also observed. ProFit based cerebral metabolite quantitation enhances the understanding and basis of the current hypothesis of MHE.
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DOI：
10.3174/ajnr.a1652
发表时间：
2009-09
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Foerster BR;Conklin LS;Petrou M;Barker PB;Schwarz KB
通讯作者：
Schwarz KB
影响因子：
25.7
作者：
Butterworth, RE
通讯作者：
Butterworth, RE
DOI：
10.1016/0167-4889(84)90042-9
发表时间：
1984-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
EVANOCHKO, WT;SAKAI, TT;GLICKSON, JD
通讯作者：
GLICKSON, JD
影响因子：
2.3
作者：
Blei, AT;Cordoba, J
通讯作者：
Cordoba, J
影响因子：
13.5
作者：
Amodio, P;Del Piccolo, F;Gatta, A
通讯作者：
Gatta, A