The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing.
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing.
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DOI：
10.1093/nar/gkn937
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发表时间：
2009-02
影响因子：
14.9
通讯作者：
Osheroff N
中科院分区：
文献类型：
--
作者：
Deweese JE;Osheroff N
拓扑异构酶 II 是一种必需酶，几乎所有需要 DNA 在细胞核内移动或打开双螺旋的过程都需要它。这种酶有助于调节 DNA 的缠绕和缠绕，并消除遗传物质中的结和缠结。为了执行其关键的生理功能，拓扑异构酶 II 会在 DNA 中产生短暂的双链断裂。因此，虽然该酶对于细胞生存是必需的，但它也具有使基因组片段化的能力。拓扑异构酶 II 的 DNA 切割/连接反应是目前临床使用的一些最成功的抗癌药物的靶点。然而，同样的反应也被认为会引发与特定类型白血病相关的染色体易位。本文将使读者熟悉拓扑异构酶 II 的 DNA 切割/连接反应及其催化循环的其他方面。此外，还将讨论该酶与抗癌药物的相互作用，以及这些药物增加拓扑异构酶 II 产生的 DNA 链断裂水平的机制。最后，它将描述增强酶介导的 DNA 切割的饮食和环境因素。
Topoisomerase II is an essential enzyme that is required for virtually every process that requires movement of DNA within the nucleus or the opening of the double helix. This enzyme helps to regulate DNA under- and overwinding and removes knots and tangles from the genetic material. In order to carry out its critical physiological functions, topoisomerase II generates transient double-stranded breaks in DNA. Consequently, while necessary for cell survival, the enzyme also has the capacity to fragment the genome. The DNA cleavage/ligation reaction of topoisomerase II is the target for some of the most successful anticancer drugs currently in clinical use. However, this same reaction also is believed to trigger chromosomal translocations that are associated with specific types of leukemia. This article will familiarize the reader with the DNA cleavage/ligation reaction of topoisomerase II and other aspects of its catalytic cycle. In addition, it will discuss the interaction of the enzyme with anticancer drugs and the mechanisms by which these agents increase levels of topoisomerase II-generated DNA strand breaks. Finally, it will describe dietary and environmental agents that enhance DNA cleavage mediated by the enzyme.
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影响因子：
20.3
作者：
Baker, RK;Kurz, EU;Kroll, DJ
通讯作者：
Kroll, DJ
影响因子：
2.9
作者：
Bandele, Omari J.;Osheroff, Neil
通讯作者：
Osheroff, Neil
DOI：
10.2174/1568011054222364
发表时间：
2005-07-01
期刊：
Current Medicinal Chemistry - Anti-Cancer Agents
影响因子：
--
作者：
Baldwin, E. L.;Osheroff, N.
通讯作者：
Osheroff, N.
影响因子：
64.8
作者：
Berger, JM;Gamblin, SJ;Wang, JC
通讯作者：
Wang, JC
DOI：
10.1073/pnas.95.14.7876
发表时间：
1998-07-07
影响因子：
11.1
作者：
Berger, JM;Fass, D;Harrison, SC
通讯作者：
Harrison, SC