Modulation of Asymmetric Division Diversity through Cytokinin and SPEECHLESS Regulatory Interactions in the Arabidopsis Stomatal Lineage.
Modulation of Asymmetric Division Diversity through Cytokinin and SPEECHLESS Regulatory Interactions in the Arabidopsis Stomatal Lineage.
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DOI：
10.1016/j.devcel.2018.08.007
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发表时间：
2018-10-08
影响因子：
11.8
通讯作者：
Bergmann DC
中科院分区：
文献类型：
--
作者：
Vatén A;Soyars CL;Tarr PT;Nimchuk ZL;Bergmann DC
器官的协调生长需要组织内和组织间细胞间的交流。在植物中，叶子的生长主要由表皮决定；在这里，气孔谱系的不对称和自我更新分裂产生了两种基本的细胞类型——铺路细胞和保护细胞，其比例反映了局部、系统和环境因素的输入。转录因子无言（SPCH）是分裂的主要调节因子，但它是否以及如何受到外部线索的影响以提供灵活的发育是一个谜。本研究表明，植物激素细胞分裂素（CK）可以作为内源信号影响气孔谱系分裂的程度和类型，并与SPCH形成调控回路。低CK信号的局部结构域是由SPCH依赖的两种抑制性a型拟南芥应答调节因子（ARR）s、ARR16和ARR17以及两种分泌肽CLE9和CLE10的细胞类型特异性活性所创建的，这两种肽与SPCH一起可以定制表皮细胞类型组成。多细胞发育需要系统信号与细胞类型特定输出的协调。vat<s:1>等人展示了植物激素细胞分裂素如何与气孔转录因子“无言”相结合，调节干细胞的不对称分裂，从而在波动的环境中产生适当数量和比例的气孔和表皮细胞，以促进叶片的生长。
Coordinated growth of organs requires communication among cells within and between tissues. In plants, leaf growth is largely dictated by the epidermis; here, asymmetric and self-renewing divisions of the stomatal lineage create two essential cell types—pavement cells and guard cells—in proportions reflecting inputs from local, systemic and environmental cues. The transcription factor SPEECHLESS (SPCH) is the prime regulator of divisions, but whether and how it is influenced by external cues to provide flexible development is enigmatic. Here we show that the phytohormone cytokinin (CK) can act as an endogenous signal to affect the extent and types of stomatal lineage divisions and forms a regulatory circuit with SPCH. Local domains of low CK signaling are created by SPCH-dependent cell-type specific activity of two repressive type-A ARABIDOPSIS RESPONSE REGULATORs (ARR)s, ARR16 and ARR17, and two secreted peptides, CLE9 and CLE10, which, together with SPCH, can customize epidermal cell-type composition. Multicellular development requires coordination of systemic signaling with cell-type specific outputs. Vatén et. al. show how the plant hormone cytokinin interfaces with the stomatal transcription factor SPEECHLESS to modulate stem-cell like asymmetric divisions, thus creating stomata and epidermal cells in appropriate numbers and proportions for leaf performance in fluctuating environments.
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影响因子：
4.3
作者：
Holst, Kerstin;Schmuelling, Thomas;Werner, Tomas
通讯作者：
Werner, Tomas
BASL控制拟南芥中的不对称细胞分裂。
影响因子：
64.5
作者：
Dong J;MacAlister CA;Bergmann DC
通讯作者：
Bergmann DC
影响因子：
4.5
作者：
Horst RJ;Fujita H;Lee JS;Rychel AL;Garrick JM;Kawaguchi M;Peterson KM;Torii KU
通讯作者：
Torii KU
影响因子：
13.6
作者：
Gruel J;Landrein B;Tarr P;Schuster C;Refahi Y;Sampathkumar A;Hamant O;Meyerowitz EM;Jönsson H
通讯作者：
Jönsson H
影响因子：
7.2
作者：
Clough, SJ;Bent, AF
通讯作者：
Bent, AF