Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis.
Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis.
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较高的膳食叶酸摄入量可降低乳腺癌风险：系统评价和荟萃分析
DOI：
10.1038/bjc.2014.155
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发表时间：
2014-04-29
影响因子：
8.8
通讯作者：
Wang, H.
中科院分区：
文献类型：
--
作者：
Chen, P.;Li, C.;Li, X.;Li, J.;Chu, R.;Wang, H.
背景：许多流行病学研究调查了叶酸摄入量、循环叶酸水平与乳腺癌风险之间的关系；方法：我们检索PubMed和MEDLINE数据库至2014年1月，对已发表的流行病学研究进行系统综述和荟萃分析，以评估叶酸摄入水平和循环叶酸水平与乳腺癌总体风险之间的关系。结果：总共确定了16项符合条件的前瞻性研究，共有744 068名参与者和26 205名乳腺癌患者，26项病例对照研究，总共16 826例病例和21 820名对照评价了叶酸摄入与乳腺癌风险的关系。前瞻性研究和病例对照研究的合并分析表明，饮食叶酸摄入量与乳腺癌风险之间存在潜在的非线性关系。前瞻性研究表明，饮食叶酸摄入量与乳腺癌风险呈U型关系。每日饮食叶酸摄入量在153400μg之间的女性与那些每天摄入153μg和400μg的女性相比，患乳腺癌的风险显著降低。病例对照研究还表明，饮食叶酸摄入量与乳腺癌风险之间存在显著的负相关。增加饮食叶酸摄入量可以降低酒精摄入量较高的女性患乳腺癌的风险，但对酒精摄入量较低的女性则不会。综合8项研究，5924名参与者，未发现循环叶酸水平与乳腺癌风险之间的显著关联。结论：我们的研究表明，叶酸可能对乳腺癌风险有预防作用，特别是对于那些饮酒水平较高的人；但剂量和时机是关键，需要更多的研究来进一步阐明这些问题。
Background:Many epidemiological studies have investigated the association between folate intake, circulating folate level and risk of breast cancer; however, the findings were inconsistent between the studies.Methods:We searched the PubMed and MEDLINE databases updated to January, 2014 and performed the systematic review and meta-analysis of the published epidemiological studies to assess the associations between folate intake level, circulating folate level and the overall risk of breast cancer.Results:In all, 16 eligible prospective studies with a total of 744 068 participants and 26 205 breast cancer patients and 26 case–control studies with a total of 16 826 cases and 21 820 controls that have evaluated the association between folate intake and breast cancer risk were identified. Pooled analysis of the prospective studies and case–control studies suggested a potential nonlinearity relationship for dietary folate intake and breast cancer risk. Prospective studies indicated a U-shaped relationship for the dietary folate intake and breast cancer risk. Women with daily dietary folate intake between 153 and 400 μg showed a significant reduced breast cancer risk compared with those< 153 μg, but not for those> 400 μg. The case–control studies also suggested a significantly negative correlation between the dietary folate intake level and the breast cancer risk. Increased dietary folate intake reduced breast cancer risk for women with higher alcohol intake level, but not for those with lower alcohol intake. No significant association between circulating folate level and breast cancer risk was found when the results of 8 identified studies with 5924 participants were pooled.Conclusions:Our studies suggested that folate may have preventive effects against breast cancer risk, especially for those with higher alcohol consumption level; however, the dose and timing are critical and more studies are warranted to further elucidate the questions.
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DOI：
10.1186/bcr921
发表时间：
2004
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Hankinson SE;Colditz GA;Willett WC
通讯作者：
Willett WC
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
4.2
作者：
Ericson, Ulrika;Borgquist, Signe;Wirfalt, Elisabet
通讯作者：
Wirfalt, Elisabet
影响因子：
3.8
作者：
Chou, Yu-Ching;Lee, Meei-Shyuan;Sun, Chien-An
通讯作者：
Sun, Chien-An
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R