Genetic diversities and phylogenetic analyses of three Chinese main ethnic groups in southwest China: A Y-Chromosomal STR study.
Genetic diversities and phylogenetic analyses of three Chinese main ethnic groups in southwest China: A Y-Chromosomal STR study.
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DOI：
10.1038/s41598-018-33751-x
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发表时间：
2018-10-18
影响因子：
4.6
通讯作者：
Han Y
中科院分区：
文献类型：
--
作者：
Chen P;He G;Zou X;Zhang X;Li J;Wang Z;Gao H;Luo L;Zhang Z;Yu J;Han Y
位于Y染色体上的短串联重复序列（STR）具有男性特异性遗传和单倍性的特性，被广泛用于法医学分析父系谱系并将男性痕迹供体与证据进行匹配。此外，Y染色体单倍型在提供对群体遗传历史的惊人见解方面发挥着重要作用。然而，贵州主要民族（汉族、苗族和布依族）Y-STR的遗传多样性和法医学特征尚不明确。在此，我们获得了贵州三个群体的Y染色体23标记单倍型，并向YHRD提交了第一批Y-STR单倍型数据。上述三个群体的HD分别为0.99990、0.99983和0.99979，DC值分别为0.9902、0.9908和0.97959。随后，通过AMOVA，MDS和系统发育关系重建，我们新研究的人群和参考群体之间的遗传分化沿沿着种族/行政区划，以及国家/大陆边界进行了调查。在种族、语言和地理多样化的人群中，发现了与我们的受试者和其他群体的显着遗传差异，其中最突出的是30个中国大陆人群中的藏族和维吾尔族，58个亚洲人群中的台湾群体和其他群体，以及非洲群体和其他群体。全球89个人群中的其他人群。黔南布依族与广西壮族的亲缘关系较近，遵义汉族与湖南汉族的亲缘关系较近，黔东南苗族与贵州水族的亲缘关系较近。新一代的Y-STR扩增系统可作为法医学鉴定、亲子鉴定甚至家系检索的辅助工具。
Short tandem repeats (STRs) located on the Y chromosome with the properties of male-specific inheritance and haploidy are widely used in forensics to analyze paternal genealogies and match male trace donors to evidence. Besides, Y-chromosomal haplotypes play an important role in providing breathtaking insights into population genetic history. However, the genetic diversity and forensic characteristics of Y-STRs in Guizhou main ethnic groups (Hans, Miaos and Bouyeis) remain uncharacterized. Here, we obtained Y-chromosomal 23-marker haplotypes in three Guizhou populations and submitted the first batch of Y-STR haplotype data to the YHRD. The HD in the aforementioned three populations are 0.99990, 0.99983, and 0.99979, respectively, and DC values are 0.9902, 0.9908, and 0.97959, respectively. Subsequently, genetic differentiation between our newly studied populations and reference groups along ethnic/administrative divisions, as well as national/continental boundaries were investigated via AMOVA, MDS, and phylogenetic relationship reconstruction. Significant genetic differentiations from our subjects and other groups are identified in ethnically, linguistically and geographically diverse populations, including most prominently Tibetans and Uyghurs among 30 mainland Chinese populations, Taiwanese groups and others among 58 Asian populations, as well as African groups and others among 89 worldwide populations. Qiannan Bouyei has a close genetic relationship with Guangxi Zhuang, and Zunyi Han and Qiandongnan Miao have close genetic affinity with Hunan Han and Guizhou Shui, respectively. Collectively, this new-generation Y-STR amplification system can be used as a supplementary tool in forensic identification and male parentage testing and even pedigree search.
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