Lithium affects rat hippocampal electrophysiology and epileptic seizures in a dose dependent manner
Lithium affects rat hippocampal electrophysiology and epileptic seizures in a dose dependent manner
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锂以剂量依赖性方式影响大鼠海马电生理学和癫痫发作
DOI：
10.1016/j.eplepsyres.2018.07.021
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发表时间：
2018-10
影响因子：
2.2
通讯作者：
Xiaoming Wang
中科院分区：
文献类型：
--
作者：
Guohui Jiang;Tianqiang Pu;Zhimin Li;Xiaodong Zhang;Ruijiao Zhou;Xing Cao;Juming Yu a;Xiaoming Wang
锂是一种经典的情绪稳定剂，可以防止细胞凋亡依赖性的细胞死亡，并且作为一种神经保护剂在治疗许多神经系统疾病中有效，已经引起了相当大的兴趣。然而,。锂对癫痫的影响仍有争议。我们发现不同剂量的锂对癫痫有影响。癫痫活动和双向调节易感性和癫痫发作的严重程度由匹罗卡品诱导。在老鼠身上。最近，有研究表明，系统地给药锂会影响髋关节的功能。基线脑电图中的海马波和波振荡。低剂量锂（10mg /kg）服用匹罗卡品的大鼠明显增加了基础伽马（30-80 Hz）和θ波的功率。（4-12 Hz）振荡，减少拉辛期4-5次发作的比例，延长潜伏期直至发作。并显著降低低级别癫痫发作频率（p< 0.05）。相反，当剂量为。与对照治疗相比，增加到40mg/kg时，锂减少了低级癫痫发作的频率。（p < 0.05）。此外，在这种高剂量下，锂显著降低了基底振荡的功率。增加了匹罗卡品诱发癫痫发作的易感性和严重程度，增强了纹波节律。postictally(80 - 200赫兹)。我们的结果为进一步研究潜在的电性提供了一个框架。锂诱导的兴奋性和抑制性神经回路失衡的生理机制。大鼠的Ulate癫痫活动。综上所述，在体内观察到基底γ和θ的幂的变化。对不同剂量锂的振荡反应可能反映了海马神经网络的反应性。
Lithium, a classic mood stabilizer, prevents apoptosis-dependent cellular death and has garnered considerable.interest as a neuroprotective agent that is efficacious in the treatment of many neurological diseases. However,.the effects of lithium in epilepsy remain controversial. We found that different doses of lithium affect epileptic.seizure activity and bidirectionally modulate the susceptibility to and severity of seizures induced by pilocarpine.in rats. Recently, it has been demonstrated that systematically administered lithium affects the powers of hip-.pocampal gamma and theta oscillations in baseline electroencephalograms. Low-dose lithium (10 mg/kg) ad-.ministered to pilocarpine-treated rats markedly increased the powers of basal gamma (30–80 Hz) and theta.(4–12 Hz) oscillations, decreased the proportion of Racine stage 4–5 seizures, extended latency until seizure.onset, and significantly reduced the frequency of lower-class seizures (p< 0.05). Conversely, when the dose was.increased to 40mg/kg, lithium reduced the frequency of lower-class seizures compared to control treatment.(p < 0.05). Further, at this high dose, lithium reduced the power of basal gamma oscillations and markedly.increased the susceptibility to and severity of pilocarpine-induced seizures and enhanced ripple rhythms.(80–200Hz) postictally. Our results provide a framework for further investigations of the underlying electro-.physiological mechanisms of lithium-induced imbalances in excitatory and inhibitory neural circuits that reg-.ulate seizure activity in rats. In conclusion, the observed in vivo changes in the powers of basal gamma and theta.oscillations in response to different doses of lithium may reflect hippocampal neural network responsiveness.
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影响因子：
25
作者：
Staley, Kevin
通讯作者：
Staley, Kevin
影响因子：
6.1
作者：
G. Chaudhary;Y. Gupta
通讯作者：
G. Chaudhary;Y. Gupta
影响因子：
2.5
作者：
R. Traub;I. Pais;A. Bibbig;F. LeBeau;E. Buhl;Helen Garner;H. Monyer;M. Whittington
通讯作者：
R. Traub;I. Pais;A. Bibbig;F. LeBeau;E. Buhl;Helen Garner;H. Monyer;M. Whittington
锂的一种新型神经保护机制，可防止 p75(NTR)-Sortilin 受体复合物的结合，并在体外和体内减轻 proNGF 诱导的神经元死亡。
影响因子：
3.4
作者：
Greenwood SG;Montroull L;Volosin M;Scharfman HE;Teng KK;Light M;Torkin R;Maxfield F;Hempstead BL;Friedman WJ
通讯作者：
Friedman WJ
影响因子：
5.3
作者：
Huh, Carey Y. L.;Goutagny, Romain;Williams, Sylvain
通讯作者：
Williams, Sylvain