Combination approaches to potentiate immune response after photodynamic therapy for cancer.
Combination approaches to potentiate immune response after photodynamic therapy for cancer.
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DOI：
10.1039/c0pp00326c
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发表时间：
2011-05
期刊：
影响因子：
--
通讯作者：
Hamblin MR
中科院分区：
文献类型：
--
作者：
St Denis TG;Aziz K;Waheed AA;Huang YY;Sharma SK;Mroz P;Hamblin MR
光动力疗法（PDT）作为癌症治疗方法已使用四十年，但尚未发展成为主流癌症治疗方法。虽然它已被证明是一种通过无毒染料和无害可见光的组合来破坏局部肿瘤的有效方法，但正是它在介导刺激宿主免疫系统方面的附加作用，使 PDT 具有更广泛应用的巨大潜力。尽管在一些动物模型中报道了 PDT 后刺激肿瘤特异性细胞毒性 T 细胞可以破坏远处肿瘤沉积物，但这仍然是例外而不是规则。这一认识促使几位研究人员测试了各种组合方法，这些方法可以增强对 PDT 后释放的肿瘤抗原的免疫识别。本综述将涵盖使用免疫刺激剂的这些组合方法，包括激活 Toll 样受体和其他病原体相关分子模式受体的微生物制剂、细胞因子生长因子以及针对调节性 T 细胞的方法。我们相信，通过了解肿瘤逃避免疫反应并中和免疫反应的方法，可以设计出更精确的方法来增强 PDT 诱导的免疫。
Photodynamic therapy (PDT) has been used as a cancer therapy for forty years but has not advanced to a mainstream cancer treatment. Although it has been shown to be an efficient way to destroy local tumors by a combination of non-toxic dyes and harmless visible light, it is its additional effects in mediating the stimulation of the host immune system that gives PDT great potential to become more widely used. Although the stimulation of tumor-specific cytotoxic T-cells that can destroy distant tumor deposits after PDT has been reported in some animal models, it remains the exception rather than the rule. This realization has prompted several investigators to test various combination approaches that could potentiate the immune recognition of tumor antigens that have been released after PDT. This review will cover these combination approaches using immunostimulants including various microbial preparations that activate Toll-like receptors and other receptors for pathogen-associated molecular patterns, cytokines growth factors, and approaches that target regulatory T-cells. We believe that by understanding the methods employed by tumors to evade immune response and neutralizing them, more precise ways of potentiating PDT-induced immunity can be devised.
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影响因子：
3.3
作者：
Dai, Tianhong;Huang, Ying-Ying;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.
影响因子：
7.2
作者：
Garg, Abhishek D.;Nowis, Dominika;Agostinis, Patrizia
通讯作者：
Agostinis, Patrizia
影响因子：
45.3
作者：
HERR, HW;SCHWALB, DM;OETTGEN, HF
通讯作者：
OETTGEN, HF
影响因子：
2.5
作者：
Kim, MS;Sung, MJ;Kim, HM
通讯作者：
Kim, HM
影响因子：
3.8
作者：
ADAMS, JL;CZUPRYNSKI, CJ
通讯作者：
CZUPRYNSKI, CJ