CCR10 is important for the development of skin-specific gammadeltaT cells by regulating their migration and location.
CCR10 is important for the development of skin-specific gammadeltaT cells by regulating their migration and location.
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DOI：
10.4049/jimmunol.1001612
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发表时间：
2010-11-15
期刊：
影响因子：
--
通讯作者：
Xiong N
中科院分区：
文献类型：
--
作者：
Jin Y;Xia M;Sun A;Saylor CM;Xiong N
与传统的αβT细胞优先驻留在次级淋巴器官中进行适应性免疫反应不同，非传统T细胞的不同亚群，如具有固有特性的γδT细胞，优先驻留在上皮组织中作为第一道防线。然而，它们特定于组织的发育机制还不是很清楚。在此，我们报道了在不同的胸腺T细胞亚群中，典型的皮肤上皮内Vγ3+T淋巴细胞(SIEL)的胎儿胸腺前体细胞(SIEL)表现出独特的归巢分子模式，包括CCR10的高水平表达，这对它们发育为SIEL是重要的。在胚胎CCR10基因敲除小鼠中，Vγ3+SIEL前体细胞在胸腺内发育正常，但在向皮肤迁移方面存在缺陷。在CCR10基因敲除的成年小鼠皮肤中，SIEL3+SIEL细胞的正常扩张部分弥补了SIEL前体细胞接种皮肤的早期缺陷，但Vγ3+SIEL细胞形态异常，在真皮组织中积聚增多。这些发现提供了明确的证据，表明CCR10通过调节SIEL前体的迁移和它们在皮肤适当区域的维持在SIELL的发育中起重要作用，并支持不同胸腺T细胞亚群的独特归巢特性在其外周位置发挥重要作用的观点。
Unlike conventional αβ T cells, which preferentially reside in secondary lymphoid organs for adaptive immune responses, various subsets of un-conventional T cells, such as the γδ T cells with innate properties, preferentially reside in epithelial tissues as the first line of defence. However, mechanisms underlying their tissue-specific development are not well understood. We herein report that among different thymic T cell subsets fetal thymic precursors of the prototypic skin intraepithelial Vγ3+ T lymphocytes (sIEL) were selected to display a unique pattern of homing molecules, including a high level of CCR10 expression that was important for their development into sIELs. In fetal CCR10 knockout mice, the Vγ3+ sIEL precursors developed normally in the thymus, but were defective in migrating into the skin. While the earlier defect in the skin-seeding by sIEL precursors was partially compensated for by their normal expansion in the skin of adult CCR10 knockout mice, the Vγ3+ sIELs displayed the abnormal morphology and increasingly accumulated in the dermal region of skin. These findings provide the definite evidence that CCR10 is important in the sIEL development by regulating the migration of sIEL precursors and their maintenance in proper regions of the skin and support the notion that unique homing properties of different thymic T cell subsets plays an important role in their peripheral location.
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影响因子：
56.9
作者：
Mallick-Wood, CA;Lewis, JM;Hayday, AC
通讯作者：
Hayday, AC
DOI：
10.1073/pnas.0912943107
发表时间：
2010-04-20
影响因子：
11.1
作者：
Jiang, Xiaodong;Campbell, James J.;Kupper, Thomas S.
通讯作者：
Kupper, Thomas S.
影响因子：
6.5
作者：
Kawai, K;Suzuki, H;Ohashi, PS
通讯作者：
Ohashi, PS
影响因子：
30.5
作者：
Luci, Carmelo;Reynders, Ana;Tomasello, Elena
通讯作者：
Tomasello, Elena
影响因子：
30.5
作者：
Lewis, Julia M.;Girardi, Michael;Tigelaar, Robert E.
通讯作者：
Tigelaar, Robert E.