Comparison of diagnostic accuracies of two- and three-dimensional MR elastography of the liver.
Comparison of diagnostic accuracies of two- and three-dimensional MR elastography of the liver.
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DOI：
10.1002/jmri.25425
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Onishi H
中科院分区：
文献类型：
--
作者：
Morisaka H;Motosugi U;Glaser KJ;Ichikawa S;Ehman RL;Sano K;Ichikawa T;Onishi H
评估成像序列（自旋回波平面成像 [EPI] 和梯度回波 [GRE]）和后处理方法（2 维 [2D] 和 3D 反演算法）对肝脏磁共振弹性成像 (MRE) 的影响，并验证 EPI-MRE3D 与传统 GRE-MRE2D 对肝纤维化分期的诊断性能。在 3-Tesla 临床 MRI 扫描仪上对柔软和轻度僵硬的模型以及 58 名慢性肝病患者进行了三种 MRE 方法（EPI-MRE3D、EPI-MRE2D 和 GRE-MRE2D），并比较了 3 种方法之间的硬度值。一项验证研究包括 73 名患有组织学肝纤维化的患者（F0-4，METAVIR 系统）。比较了 EPI-MRE3D 和 GRE-MRE2D 的受试者工作特征曲线下面积 (AUC) 以及诊断显着纤维化 (F3-4) 和肝硬化 (F4) 的准确性。 EPI-MRE3D 软体模和轻度僵硬体模的刚度值为 2.4 kPa 和 4.0 kPa； EPI-MRE2D 为 2.6 千帕 [kPa] 和 4.2kPa； GRE-MRE2D 为 2.7 kPa 和 4.2kPa。在患者中，EPI-MRE3D 提供的硬度值显着低于其他方法 (p<0.001)。然而，GRE-MRE2D 和 EPI-MRE2D 之间没有显着差异 (p=0.12)。 EPI-MRE3D 和 GRE-MRE2D 在诊断显着纤维化 (F3-4) 和肝硬化 (F4) 时的 AUC 和准确度在统计上相当（均 p<0.005）。 EPI-MRE3D 显示出比传统 GRE-MRE2D 更低的肝脏硬度值。 EPI-MRE3D 和 GRE-MRE2D 对于肝纤维化分期的诊断性能相当。
To evaluate the effect of imaging sequence (spin-echo echo-planar imaging [EPI] and gradient-echo [GRE]) and postprocessing method (2-dimensional [2D] and 3D inversion algorithms) on liver magnetic resonance elastography (MRE) and to validate the diagnostic performance of EPI-MRE3D versus conventional GRE-MRE2D for liver fibrosis staging. Three MRE methods (EPI-MRE3D, EPI-MRE2D, and GRE-MRE2D) were performed on soft and mildly stiff phantoms and 58 patients with chronic liver disease at a 3-Tesla clinical MRI scanner, and stiffness values were compared among the 3 methods. A validation study comprised 73 patients with histological liver fibrosis (F0–4, METAVIR system). Areas under the receiver operating characteristic curves (AUCs) and accuracies for diagnosing significant fibrosis (F3–4) and cirrhosis (F4) were compared between EPI-MRE3D and GRE-MRE2D. Stiffness values of soft and mildly stiff phantoms were 2.4 kPa and 4.0kPa by EPI-MRE3D; 2.6 kilopascal [kPa] and 4.2kPa by EPI-MRE2D; and 2.7 kPa and 4.2kPa by GRE-MRE2D. In patients, EPI-MRE3D provided significantly lower stiffness values than other methods (p<0.001). However, there was no significant difference between GRE-MRE2D and EPI-MRE2D (p=0.12). The AUCs and accuracies of EPI-MRE3D and GRE-MRE2D were statistically equivalent in the diagnoses of significant fibrosis (F3–4) and cirrhosis (F4) (all p<0.005). EPI-MRE3D showed lower modestly liver stiffness values than conventional GRE-MRE2D. The diagnostic performances of EPI-MRE3D and GRE-MRE2D were equivalent for liver fibrosis staging.
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影响因子：
29.4
作者：
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通讯作者：
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影响因子：
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