Herbal Medicine, Gut Microbiota, and COVID-19.
Herbal Medicine, Gut Microbiota, and COVID-19.
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DOI：
10.3389/fphar.2021.646560
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发表时间：
2021
影响因子：
5.6
通讯作者：
Deng L
中科院分区：
文献类型：
--
作者：
Chen Z;Lv Y;Xu H;Deng L
冠状病毒病19（COVID-19）是由严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）引起的呼吸道疾病，已发展为全球大流行病，死亡率很高。COVID-19的症状从轻微的流感样症状（包括咳嗽和发烧）到危及生命的并发症不等。仍有相当数量的COVID-19患者出现肠道症状，包括恶心、呕吐和腹泻。胃肠道可能是SARS-CoV-2的靶器官之一。血管紧张素转换酶2（ACE 2）是SARS冠状病毒2型的主要受体，在肠道细胞中大量表达。ACE 2将氨基酸营养不良与微生物生态和肠道炎症联系起来。肠道植物群失衡和内毒素血症可能加速COVID-19的进展。许多草药已经证明了与COVID-19治疗相关的特性，通过支持受病毒影响的身体器官和系统。中药可以恢复肠道植物群的结构，这可能进一步调节SARS-CoV-2感染后的免疫功能。中药对肠道植物群的调节可能有助于该病的治疗和康复。了解调节肠道植物群的草药在对抗呼吸道病毒感染和维持肠道植物群平衡中的作用，可以为预防和治疗COVID-19提供新的思路。
Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which has grown to a worldwide pandemic with substantial mortality. The symptoms of COVID-19 range from mild flu-like symptoms, including cough and fever, to life threatening complications. There are still quite a number of patients with COVID-19 showed enteric symptoms including nausea, vomiting, and diarrhea. The gastrointestinal tract may be one of the target organs of SARS-CoV-2. Angiotensin converting enzyme 2 (ACE2) is the main receptor of SARS-CoV-2 virus, which is significantly expressed in intestinal cells. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Intestinal flora imbalance and endotoxemia may accelerate the progression of COVID-19. Many herbs have demonstrated properties relevant to the treatment of COVID-19, by supporting organs and systems of the body affected by the virus. Herbs can restore the structure of the intestinal flora, which may further modulate the immune function after SARS-CoV-2 infection. Regulation of intestinal flora by herbal medicine may be helpful for the treatment and recovery of the disease. Understanding the role of herbs that regulate intestinal flora in fighting respiratory virus infections and maintaining intestinal flora balance can provide new ideas for preventing and treating COVID-19.
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DOI：
10.1038/nri3535
发表时间：
2013-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.7
作者：
Cattelan AM;Di Meco E;Trevenzoli M;Frater A;Ferrari A;Villano M;Gomiero F;Carretta G;Sasset L
通讯作者：
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影响因子：
3.1
作者：
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通讯作者：
Podolsky, DK
DOI：
10.1097/00042737-199804000-00009
发表时间：
1998-04-01
影响因子：
2.1
作者：
Abuzakouk, M;Carton, J;O'Farrelly, C
通讯作者：
O'Farrelly, C
影响因子：
2.4
作者：
Cai, Bingna;Wan, Peng;Pan, Jianyu
通讯作者：
Pan, Jianyu