Current status of mucins in the diagnosis and therapy of cancer.
Current status of mucins in the diagnosis and therapy of cancer.
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DOI：
10.1002/biof.64
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发表时间：
2009-11
期刊：
影响因子：
6
通讯作者：
Batra, Surinder K.
中科院分区：
文献类型：
--
作者：
Rachagani, Satyanarayana;Torres, Maria P.;Moniaux, Nicolas;Batra, Surinder K.
粘蛋白是粘液中含量最丰富的高分子量糖蛋白。它们的性质和糖基化含量决定了粘弹性分泌物的生化和生物物理性质，指出了粘弹性分泌物在分化、细胞黏附、免疫反应和细胞信号转导等多种生物学功能中的重要作用。粘蛋白由体内特殊的上皮细胞在管状器官中表达。它们的异常表达在各种炎症性或恶性疾病中都有很好的记录。从预后的角度来看，它们的表达和糖基化的改变与恶性疾病的发生发展有关。因此，粘蛋白可以作为区分正常和疾病的有价值的标记物。事实上，糖基化模式的这种变化在寡糖侧链上产生了几个表位，可以用作诊断和/或预后标记物。此外，这些特有的肿瘤相关表位被广泛用作恶性上皮细胞的合适免疫靶点。因此，为了尽早发现和治疗癌症，粘蛋白被分析为潜在的疾病标记物，用于诊断、进展和治疗目的。本文就粘蛋白在正常和病理状态下的分布现状及其在癌症诊断和治疗中的临床应用作一综述。
Mucins are the most abundant high molecular weight glycoproteins in mucus. Their nature and glycosylation content dictates the biochemical and biophysical properties of viscoelastic secretions, pointing out an important role in diverse biological functions, such as differentiation, cell adhesions, immune responses, and cell signaling. Mucins are expressed in tubular organs by specialized epithelial cells in the body. Their aberrant expression is well documented in a variety of inflammatory or malignant diseases. From a prognosis point of view, their expression and alterations in glycosylation are associated with the development and progression of malignant diseases. Therefore, mucins can be used as valuable markers to distinguish between normal and disease conditions. Indeed, this alteration in glycosylation patterns generates several epitopes in the oligosaccharide side chains that can be used as diagnostic and/or prognostic markers. Furthermore, these characteristic tumor-associated epitopes are extensively used as appropriate immunotargets of malignant epithelial cells. Therefore, in an effort to detect and treat cancer at the earliest stage possible, mucins are analyzed as potential markers of disease for diagnosis, progression, and for therapeutic purposes. In this review, we focused on the current status of the distribution of mucins in normal and pathologic conditions and their clinical use both in cancer diagnosis and therapeutics treatments.
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影响因子：
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