The Interleukin-20 Cytokine Family in Liver Disease.
The Interleukin-20 Cytokine Family in Liver Disease.
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白细胞介素 - 20 细 胞 因 子 家 族 与 肝 脏 疾 病
DOI：
10.3389/fimmu.2018.01155
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发表时间：
2018
影响因子：
7.3
通讯作者：
Francés R
中科院分区：
文献类型：
--
作者：
Caparrós E;Francés R
肝脏炎症和慢性损伤的三个主要原因是病毒性肝炎，酒精消耗和非酒精性脂肪性肝炎，所有这些都可能导致肝纤维化，肝硬化和肝细胞癌，这反过来又可能促使需要肝移植。白细胞介素（IL）-20是IL-10家族细胞因子的亚家族部分，其帮助肝脏对损伤和疾病作出反应，它们参与组织稳态的控制以及在该器官中产生的免疫应答。在肝脏炎症平衡中研究得最好的家族成员是IL-22细胞因子，其一方面可能在纤维化进展中具有保护作用，但另一方面可能在肝细胞癌发展中诱导肝组织易感性。该家族的其他成员也可能执行这种双重功能，因为它们中的一些共享IL受体亚基并通过共同的细胞内途径发出信号。研究人员开始考虑在肝病中靶向IL-20亚家族成员的潜力。最近探索的miRNA在IL-22和IL-24的转录调节中的作用为控制局部免疫应答和限制器官损伤的有前途的新方法打开了大门。IL-20 RA细胞因子受体也被归类为在非酒精性脂肪性肝炎中受miRNA控制。此外，研究人员已经提出将抗炎药与IL-22结合作为酒精性肝病（ALD）治疗的保肝IL，并且用于管理严重酒精性肝变性的IL的临床试验正在进行中。在这篇综述中，我们重点探讨IL-20亚家族细胞因子在病毒性肝炎、ALD、非酒精性脂肪性肝炎和肝细胞癌中的作用，以及描绘迄今为止在IL-20亚家族细胞因子治疗肝病的可能性方面探索的主要策略。
The three main causes of inflammation and chronic injury in the liver are viral hepatitis, alcohol consumption, and non-alcoholic steatohepatitis, all of which can lead to liver fibrosis, cirrhosis, and hepatocellular carcinoma, which in turn may prompt the need for liver transplant. The interleukin (IL)-20 is a subfamily part of the IL-10 family of cytokines that helps the liver respond to damage and disease, they participate in the control of tissue homeostasis, and in the immunological responses developed in this organ. The best-studied member of the family in inflammatory balance of the liver is the IL-22 cytokine, which on the one hand may have a protective role in fibrosis progression but on the other may induce liver tissue susceptibility in hepatocellular carcinoma development. Other members of the family might also carry out this dual function, as some of them share IL receptor subunits and signal through common intracellular pathways. Investigators are starting to consider the potential for targeting IL-20 subfamily members in liver disease. The recently explored role of miRNA in the transcriptional regulation of IL-22 and IL-24 opens the door to promising new approaches for controlling the local immune response and limiting organ injury. The IL-20RA cytokine receptor has also been classified as being under miRNA control in non-alcoholic steatohepatitis. Moreover, researchers have proposed combining anti-inflammatory drugs with IL-22 as a hepatoprotective IL for alcoholic liver disease (ALD) treatment, and clinical trials of ILs for managing severe alcoholic-derived liver degeneration are ongoing. In this review, we focus on exploring the role of the IL-20 subfamily of cytokines in viral hepatitis, ALD, non-alcoholic steatohepatitis, and hepatocellular carcinoma, as well as delineating the main strategies explored so far in terms of therapeutic possibilities of the IL-20 subfamily of cytokines in liver disease.
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DOI：
10.1152/ajpgi.00094.2015
发表时间：
2016-03-01
影响因子：
4.5
作者：
Hartmann, Phillipp;Seebauer, Caroline T.;Schnabl, Bernd
通讯作者：
Schnabl, Bernd
影响因子：
30.5
作者：
Duhen, Thomas;Geiger, Rebekka;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
2.5
作者：
Brandl K;Schnabl B
通讯作者：
Schnabl B
影响因子：
5
作者：
Gallagher, G;Dickensheets, H;Kotenko, SV
通讯作者：
Kotenko, SV
影响因子：
15.9
作者：
Bataller, R;Schwabe, RF;Brenner, DA
通讯作者：
Brenner, DA