Myelin basic protein autoantibodies, white matter disease and stroke outcome.
Myelin basic protein autoantibodies, white matter disease and stroke outcome.
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DOI：
10.1016/j.jneuroim.2012.08.006
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发表时间：
2012-11-15
影响因子：
3.3
通讯作者：
Becker, Kyra
中科院分区：
文献类型：
--
作者：
Shibata, Dean;Cain, Kevin;Tanzi, Patricia;Zierath, Dannielle;Becker, Kyra
中风幸存者体内存在针对大脑抗原的抗体。在这项研究中，我们评估了对白质抗原的自身抗体反应，以及它们与白质疾病和中风预后的相关性。112例缺血性卒中患者在1个或多个时间点检测抗髓鞘碱性蛋白(MBP)、蛋白脂蛋白(PLP)和破伤风类毒素(TT)抗体(免疫球蛋白G[IgG])。与对照组(N=40)相比，卒中后早期TT的免疫球蛋白滴度总体下降。脑白质疾病患者在中风后30天，脑白质疾病患者的MBP和PLP抗体滴度均升高，且抗MBP抗体与较差的预后相关。白质抗体，尤其是MBP抗体的潜在病理后果值得进一步研究。
Antibodies to brain antigens are present in stroke survivors. In this study, we assessed autoantibody responses to white matter antigens, their correlation to white matter disease and stroke outcome. Antibody titers (immunoglobulin G [igG]) to myelin basic protein (MBP), proteolipid protein (PLP) and tetanus toxoid (TT) were available at one or more time points for 112 subjects with ischemic stroke. In comparison to the control subjects (N=40), there was a global decrease in IgG titers to TT early after stroke. Patients with white matter disease on magnetic resonance imaging had elevated titers of antibodies to both MBP and PLP at 30 days after stroke, and anti-MBP antibodies were associated with worse outcome. The potential pathologic consequences of antibodies to white matter, especially MBP, is deserving of further investigation.
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影响因子：
9.3
作者：
Dambinova, SA;Khounteev, GA;Skoromets, AA
通讯作者：
Skoromets, AA
影响因子：
2.4
作者：
Chang, Li-Teh;Yuen, Chun-Man;Yip, Hon-Kan
通讯作者：
Yip, Hon-Kan
DOI：
10.2174/187152807783334337
发表时间：
2007-12-01
期刊：
Inflammation & Allergy Drug Targets
影响因子：
--
作者：
Albaiceta, Guillermo M.;Pedreira, Paula R.;Taboada, Francisco
通讯作者：
Taboada, Francisco
影响因子：
8.3
作者：
Becker KJ;Kalil AJ;Tanzi P;Zierath DK;Savos AV;Gee JM;Hadwin J;Carter KT;Shibata D;Cain KC
通讯作者：
Cain KC
影响因子：
8.3
作者：
Jalal FY;Yang Y;Thompson J;Lopez AC;Rosenberg GA
通讯作者：
Rosenberg GA