Embryo movements regulate tendon mechanical property development.
Embryo movements regulate tendon mechanical property development.
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DOI：
10.1098/rstb.2017.0325
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发表时间：
2018-09-24
期刊：
影响因子：
--
通讯作者：
Kuo CK
中科院分区：
文献类型：
--
作者：
Pan XS;Li J;Brown EB;Kuo CK
肌腱将力从肌肉传递到骨骼，以使骨骼能够运动。在发育过程中，肌腱在胚胎开始运动时就开始承受负荷。利用鸡胚模型，这项研究表明，胚胎运动频率的改变会导致跟腱弹性模量发生变化。特别是，瘫痪会导致模量降低，而运动过度则会导致模量增加。瘫痪还会导致赖氨酰氧化酶（LOX）活性水平降低，我们之前已证明该酶是交联介导的肌腱力学性能细化所必需的。此外，抑制赖氨酰氧化酶活性可消除运动过度引起的模量增加。综上所述，我们的研究结果表明胚胎运动对肌腱力学性能的发育至关重要，并表明赖氨酰氧化酶参与了这一过程。这些令人兴奋的发现拓展了目前关于发育过程中功能性肌腱如何形成的知识，并可能指导未来治疗子宫内异常机械负荷相关肌腱缺陷的临床方法。
本文是“发育的力学”西奥·墨菲会议特刊的一部分。
Tendons transmit forces from muscles to bones to enable skeletal motility. During development, tendons begin to bear load at the onset of embryo movements. Using the chick embryo model, this study showed that altered embryo movement frequency led to changes in elastic modulus of calcaneal tendon. In particular, paralysis led to decreased modulus, whereas hypermotility led to increased modulus. Paralysis also led to reductions in activity levels of lysyl oxidase (LOX), an enzyme that we previously showed is required for cross-linking-mediated elaboration of tendon mechanical properties. Additionally, inhibition of LOX activity abrogated hypermotility-induced increases in modulus. Taken together, our findings suggest embryo movements are critical for tendon mechanical property development and implicate LOX in this process. These exciting findings expand current knowledge of how functional tendons form during development and could guide future clinical approaches to treat tendon defects associated with abnormal mechanical loading in utero. This article is part of the Theo Murphy meeting issue ‘Mechanics of development’.
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影响因子：
9.7
作者：
Marturano, Joseph E.;Xylas, Joanna F.;Sridharan, Gautham V.;Georgakoudi, Irene;Kuo, Catherine K.
通讯作者：
Kuo, Catherine K.
影响因子：
2.4
作者：
Brown JP;Finley VG;Kuo CK
通讯作者：
Kuo CK
影响因子：
2.4
作者：
Pitsillides, AA
通讯作者：
Pitsillides, AA
影响因子：
4.1
作者：
Kuo, Catherine K.;Tuan, Rocky S.
通讯作者：
Tuan, Rocky S.
影响因子：
2.7
作者：
Heywood, JL;McEntee, GM;Stickland, NC
通讯作者：
Stickland, NC