Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention.
Altered Cerebellar White Matter in Sensory Processing Dysfunction Is Associated With Impaired Multisensory Integration and Attention.
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DOI：
10.3389/fpsyg.2020.618436
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发表时间：
2020
影响因子：
3.8
通讯作者：
Mukherjee P
中科院分区：
文献类型：
--
作者：
Narayan A;Rowe MA;Palacios EM;Wren-Jarvis J;Bourla I;Gerdes M;Brandes-Aitken A;Desai SS;Marco EJ;Mukherjee P
感觉加工功能障碍（SPD）的特征是对来自环境的感觉信息的反应存在行为观察差异。虽然小脑参与正常的感觉处理，但尚未在SPD中进行检查。对SPD患儿（n = 42）和正常发育对照（TDC; n = 39）的弥散张量成像扫描，比较其在以下小脑束的分数各向异性（FA）、平均弥散性（MD）、径向弥散性（RD）和轴向弥散性（AD）：小脑中脚（MCP）、小脑上脚（SCP）和脑脚（CP）。与TDC相比，SPD患儿的SCP和MCP的显微结构完整性降低，表现为FA减少，MD和RD增加，这与异常的听觉行为、多感觉整合和注意有关，但与触觉行为或听觉辨别的直接测量无关。相比之下，SPD的CP显微结构完整性下降与异常的触觉和听觉行为以及听觉辨别的直接测量相关，而与多感觉整合或注意无关。因此，SPD患者小脑白质组织的改变与复杂的感觉行为和注意力有关，这促使我们进一步考虑诊断措施和治疗方法，以更好地为患者服务。
Sensory processing dysfunction (SPD) is characterized by a behaviorally observed difference in the response to sensory information from the environment. While the cerebellum is involved in normal sensory processing, it has not yet been examined in SPD. Diffusion tensor imaging scans of children with SPD (n = 42) and typically developing controls (TDC; n = 39) were compared for fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) across the following cerebellar tracts: the middle cerebellar peduncles (MCP), superior cerebellar peduncles (SCP), and cerebral peduncles (CP). Compared to TDC, children with SPD show reduced microstructural integrity of the SCP and MCP, characterized by reduced FA and increased MD and RD, which correlates with abnormal auditory behavior, multisensory integration, and attention, but not tactile behavior or direct measures of auditory discrimination. In contradistinction, decreased CP microstructural integrity in SPD correlates with abnormal tactile and auditory behavior and direct measures of auditory discrimination, but not multisensory integration or attention. Hence, altered cerebellar white matter organization is associated with complex sensory behavior and attention in SPD, which prompts further consideration of diagnostic measures and treatments to better serve affected individuals.
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影响因子：
3.5
作者：
Baumann, Oliver;Borra, Ronald J.;Bower, James M.;Cullen, Kathleen E.;Habas, Christophe;Ivry, Richard B.;Leggio, Maria;Mattingley, Jason B.;Molinari, Marco;Moulton, Eric A.;Paulin, Michael G.;Pavlova, Marina A.;Schmahmann, Jeremy D.;Sokolov, Arseny A.
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作者：
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通讯作者：
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影响因子：
3.5
作者：
McMahon, Kibby;Anand, Deepika;Rosenthal, M. Zachary
通讯作者：
Rosenthal, M. Zachary
DOI：
10.1017/s1355617720000417
发表时间：
2020-11-01
影响因子：
2.6
作者：
Ailion, Alyssa S.;King, Tricia Z.;Crosson, Bruce
通讯作者：
Crosson, Bruce