The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties.
The interferon antagonistic activities of the V proteins from two strains of Newcastle disease virus correlate with their known virulence properties.
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DOI：
10.1016/j.virusres.2009.10.020
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发表时间：
2010-01
期刊：
影响因子：
5
通讯作者：
Iorio, Ronald M.
中科院分区：
文献类型：
--
作者：
Alamares, Judith G.;Elankumaran, Subbiah;Samal, Siba K.;Iorio, Ronald M.
新城疫病毒 (NDV) 是一种禽副粘病毒，存在数百种毒力特性差异很大的毒株。 NDV V 蛋白表现出干扰素 (IFN) 拮抗活性，这有助于增强病毒的毒力。在拯救表达绿色荧光蛋白的重组新城疫病毒 (NDV-GFP) 的测定中，比较了无毒株 La Sota 和中等毒力株 Beaudette C (BC) 的 V 蛋白的 IFN 拮抗活性。与两种病毒的毒力特性一致，BC V 蛋白拯救 NDV-GFP 复制的能力比 La Sota V 蛋白高 4 倍。 V C 端区域以及 N 端区域的四个氨基酸差异导致两种 V 蛋白之间的 IFN 拮抗活性存在差异。
Newcastle disease virus (NDV) is an avian paramyxovirus that exists as hundreds of strains with widely different virulence properties. The NDV V protein exhibits interferon (IFN) antagonistic activity, which contributes to the virulence of the virus. The IFN antagonistic activities of the V proteins from the avirulent strain La Sota and the moderately virulent strain Beaudette C (BC) were compared in an assay for the rescue of a recombinant NDV expressing the green fluorescent protein (NDV-GFP). Consistent with the virulence properties of the two viruses, the BC V protein exhibits a 4-fold greater ability to rescue replication of NDV-GFP than the La Sota V protein. Four amino acid differences in the C-terminal region of V, as well as the N-terminal region, contribute to the difference in IFN antagonistic activity between the two V proteins.
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