Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing.
Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing.
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DOI：
10.1007/s11302-011-9233-z
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发表时间：
2011-06
影响因子：
3.5
通讯作者：
Kucharska, Marta
中科院分区：
文献类型：
--
作者：
Gendaszewska-Darmach, Edyta;Kucharska, Marta
随着细胞外核苷酸参与正常生理和病理过程的兴趣越来越大，P2受体激动剂和拮抗剂可能具有治疗潜力已变得明显。P2Y2受体激动剂(地夸福索四钠和地那福索四钠)分别处于治疗干眼症和囊性纤维化的临床试验的第三阶段。硫代吡啶衍生物氯吡格雷和噻氯匹定(血小板P2Y12受体的拮抗剂)已在心血管药物中使用了近十年。由于ATP和UTP已被证明具有许多伤口愈合因子的特征，因此嘌呤和嘧啶也可能在伤口愈合中具有治疗潜力。最近的研究表明，细胞外核苷酸参与伤口修复的所有阶段：止血、炎症、组织形成和组织重塑。这篇综述主要集中在有效的嘌呤和嘧啶，它们调节着许多对伤口愈合至关重要的生理过程。
With a growing interest of the involvement of extracellular nucleotides in both normal physiology and pathology, it has become evident that P2 receptor agonists and antagonists may have therapeutic potential. The P2Y2 receptor agonists (diquafosol tetrasodium and denufosol tetrasodium) are in the phase 3 of clinical trials for dry eye and cystic fibrosis, respectively. The thienopyridine derivatives clopidogrel and ticlopidine (antagonists of the platelet P2Y12 receptor) have been used in cardiovascular medicine for nearly a decade. Purines and pyrimidines may be of therapeutic potential also in wound healing since ATP and UTP have been shown to have many hallmarks of wound healing factors. Recent studies have demonstrated that extracellular nucleotides take part in all phases of wound repair: hemostasis, inflammation, tissue formation, and tissue remodeling. This review is focused on the potent purines and pyrimidines which regulate many physiological processes important for wound healing.
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DOI：
10.1083/jcb.153.3.491
发表时间：
2001-04-30
期刊：
The Journal of cell biology
影响因子：
--
作者：
Erb L;Liu J;Ockerhausen J;Kong Q;Garrad RC;Griffin K;Neal C;Krugh B;Santiago-Pérez LI;González FA;Gresham HD;Turner JT;Weisman GA
通讯作者：
Weisman GA
影响因子：
6.4
作者：
Deli, Tamas;Varga, Norbert;Timar, Jozsef
通讯作者：
Timar, Jozsef
DOI：
10.1007/bf01931108
发表时间：
1995-03-15
期刊：
EXPERIENTIA
影响因子：
--
作者：
BODIN, P;BURNSTOCK, G
通讯作者：
BURNSTOCK, G
影响因子：
13.8
作者：
Abbracchio, MP;Boeynaems, JM;Burnstock, G
通讯作者：
Burnstock, G
影响因子：
5.5
作者：
Chen, Y;Shukla, A;Junger, WG
通讯作者：
Junger, WG