Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan.
Familial aggregation of gout and relative genetic and environmental contributions: a nationwide population study in Taiwan.
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DOI：
10.1136/annrheumdis-2013-204067
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发表时间：
2015-02
影响因子：
27.4
通讯作者：
Doherty M
中科院分区：
文献类型：
--
作者：
Kuo CF;Grainge MJ;See LC;Yu KH;Luo SF;Valdes AM;Zhang W;Doherty M
目的：研究痛风的家族聚集性，并估计一般人群中对痛风易感性的遗传和环境影响。其中1 045 059人有医生诊断的痛风。我们估计了有一级和二级亲属患病的个体痛风的相对风险（RR），以及基因（遗传性）、家庭成员共有环境和非共有环境对痛风易感性的相对贡献。痛风的相对危险度在有患病一级亲属的个体中显著更高(男性，1.91 (95% CI 1.90 ~ 1.93)；女性，1.97 (95% CI 1.94至1.99))，以及有患病二度亲属的患者(男性，1.27 (95% CI 1.23至1.31)；女性，1.40 (95% CI 1.35 - 1.46))。双胞胎、兄弟姐妹、后代、父母、孙辈、侄子/侄女、叔叔/阿姨和祖父母患病个体的相对危险度（95% ci）分别为8.02（6.95 ~ 9.26）、2.59（2.54 ~ 2.63）、1.96（1.95 ~ 1.97）、1.93（1.91 ~ 1.94）、1.48（1.43 ~ 1.53）、1.40（1.32 ~ 1.47）、1.31（1.24 ~ 1.39）和1.26（1.21 ~ 1.30）。遗传力、共同环境因素和非共同环境因素对痛风表型变异的相对贡献率男性分别为35.1%、28.1%和36.8%，女性分别为17.0%、18.5%和64.5%。这项基于人群的研究证实，痛风在家庭中聚集。有家族病史的人患痛风的风险更高。遗传和环境因素对痛风病因有影响，相对影响是两性二态的。
To examine familial aggregation of gout and to estimate the heritability and environmental contributions to gout susceptibility in the general population. Using data from the National Health Insurance (NHI) Research Database in Taiwan, we conducted a nationwide cross-sectional study of data collected from 22 643 748 beneficiaries of the NHI in 2004; among them 1 045 059 individuals had physician-diagnosed gout. We estimated relative risks (RR) of gout in individuals with affected first-degree and second-degree relatives and relative contributions of genes (heritability), common environment shared by family members and non-shared environment to gout susceptibility. RRs for gout were significantly higher in individuals with affected first-degree relatives (men, 1.91 (95% CI 1.90 to 1.93); women, 1.97 (95% CI 1.94 to 1.99)) and also in those with affected second-degree relatives (men, 1.27 (95% CI 1.23 to 1.31); women, 1.40 (95% CI 1.35 to 1.46)). RRs (95% CIs) for individuals with an affected twin, sibling, offspring, parent, grandchild, nephew/niece, uncle/aunt and grandparent were 8.02 (6.95 to 9.26), 2.59 (2.54 to 2.63), 1.96 (1.95 to 1.97), 1.93 (1.91 to 1.94), 1.48 (1.43 to 1.53), 1.40 (1.32 to 1.47), 1.31 (1.24 to 1.39), and 1.26 (1.21 to 1.30), respectively. The relative contributions of heritability, common and non-shared environmental factors to phenotypic variance of gout were 35.1, 28.1 and 36.8% in men and 17.0, 18.5 and 64.5% in women, respectively. This population-based study confirms that gout aggregates within families. The risk of gout is higher in people with a family history. Genetic and environmental factors contribute to gout aetiology, and the relative contributions are sexually dimorphic.
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影响因子：
--
作者：
Bhole, Vidula;de Vera, Mary;Choi, Hyon
通讯作者：
Choi, Hyon
影响因子：
27.4
作者：
Annemans L;Spaepen E;Gaskin M;Bonnemaire M;Malier V;Gilbert T;Nuki G
通讯作者：
Nuki G
影响因子：
37.8
作者：
Choi, Hyon K.;Curhan, Gary
通讯作者：
Curhan, Gary
影响因子：
168.9
作者：
Dehghan, Abbas;Kottgen, Anna;Yang, Qiong;Hwang, Shih Jen;Kao, W. H. Linda;Rivadeneira, Fernando;Boerwinkle, Eric;Levy, Daniel;Hofman, Albert;Astor, Brad C.;Benjamin, Emelia J.;van Duijn, Cornelia M.;Witteman, Jacqueline C.;Coresh, Josef;Fox, Caroline S.
通讯作者：
Fox, Caroline S.
影响因子：
4.5
作者：
Kolz M;Johnson T;Sanna S;Teumer A;Vitart V;Perola M;Mangino M;Albrecht E;Wallace C;Farrall M;Johansson A;Nyholt DR;Aulchenko Y;Beckmann JS;Bergmann S;Bochud M;Brown M;Campbell H;EUROSPAN Consortium;Connell J;Dominiczak A;Homuth G;Lamina C;McCarthy MI;ENGAGE Consortium;Meitinger T;Mooser V;Munroe P;Nauck M;Peden J;Prokisch H;Salo P;Salomaa V;Samani NJ;Schlessinger D;Uda M;Völker U;Waeber G;Waterworth D;Wang-Sattler R;Wright AF;Adamski J;Whitfield JB;Gyllensten U;Wilson JF;Rudan I;Pramstaller P;Watkins H;PROCARDIS Consortium;Doering A;Wichmann HE;KORA Study;Spector TD;Peltonen L;Völzke H;Nagaraja R;Vollenweider P;Caulfield M;WTCCC;Illig T;Gieger C
通讯作者：
Gieger C