Vascularization Strategies for Peripheral Nerve Tissue Engineering.
Vascularization Strategies for Peripheral Nerve Tissue Engineering.
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DOI：
10.1002/ar.23919
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发表时间：
2018-10
期刊：
影响因子：
--
通讯作者：
Phillips JB
中科院分区：
文献类型：
--
作者：
Muangsanit P;Shipley RJ;Phillips JB
血管化在治疗神经损伤中起着重要作用，特别是为了避免在用于大而长的神经缺损的神经移植物中观察到的中央坏死。众所周知，足够的血管化可以维持细胞存活并维持细胞在组织工程构建体中的整合。一些研究也表明血管化影响神经再生。在这些研究的推动下，采用各种不同的技术开发了血管化神经移植物，尽管供体部位的发病率和有限的神经供应仍然是显著的缺点。组织工程学提供了一个令人兴奋的替代方法，预制血管化的神经结构，可以克服移植物的局限性。在这篇综述文章中，我们专注于血管化在神经再生中的作用，讨论了各种方法来生成血管化神经结构和组织工程和数学建模的贡献，以帮助开发血管化工程神经结构，说明这些方面的例子，从我们的研究经验。Anat Rec，301：1657-1667，2018。© 2018作者The Anatomical Record由Wiley Periodicals，Inc.出版。代表美国解剖学家协会
Vascularization plays a significant role in treating nerve injury, especially to avoid the central necrosis observed in nerve grafts for large and long nerve defects. It is known that sufficient vascularization can sustain cell survival and maintain cell integration within tissue‐engineered constructs. Several studies have also shown that vascularization affects nerve regeneration. Motivated by these studies, vascularized nerve grafts have been developed using various different techniques, although donor site morbidity and limited nerve supply remain significant drawbacks. Tissue engineering provides an exciting alternative approach to prefabricate vascularized nerve constructs which could overcome the limitations of grafts. In this review article, we focus on the role of vascularization in nerve regeneration, discussing various approaches to generate vascularized nerve constructs and the contribution of tissue engineering and mathematical modeling to aid in developing vascularized engineered nerve constructs, illustrating these aspects with examples from our research experience. Anat Rec, 301:1657–1667, 2018. © 2018 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.
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影响因子：
3.3
作者：
Coy RH;Evans OR;Phillips JB;Shipley RJ
通讯作者：
Shipley RJ
影响因子：
5.6
作者：
Berthod, F;Germain, L;Auger, FA
通讯作者：
Auger, FA
影响因子：
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作者：
Gao H;You Y;Zhang G;Zhao F;Sha Z;Shen Y
通讯作者：
Shen Y
影响因子：
14.5
作者：
BELL, MA;WEDDELL, AGM
通讯作者：
WEDDELL, AGM
影响因子：
2.1
作者：
BEST, TJ;MACKINNON, SE
通讯作者：
MACKINNON, SE