Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review).
Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review).
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DOI：
10.3892/ol.2015.2884
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发表时间：
2015-03
期刊：
影响因子：
2.9
通讯作者：
DE Araújo JM
中科院分区：
文献类型：
--
作者：
Fernandes JV;DE Medeiros Fernandes TA;DE Azevedo JC;Cobucci RN;DE Carvalho MG;Andrade VS;DE Araújo JM
炎症是一种防御入侵因素和有害分子的策略，在刺激后立即激活，涉及细胞因子和趋化因子的释放，激活先天免疫反应。这些介质共同作用，增加血流和血管通透性，促进效应细胞募集到损伤部位。随着损伤的解决和刺激的去除，炎症被禁用，但如果刺激持续，炎症就会变成慢性的，并与癌症密切相关。这很可能是因为炎症导致伤口无法愈合，需要不断更新细胞，这增加了肿瘤转化的风险。吞噬作用产生的碎片，包括氧和氮的活性物种，会对已经被白三烯和前列腺素破坏的DNA造成损害，对炎症和各种致癌途径产生影响。慢性炎症、持续感染和癌症之间存在关联，其中致癌作用由自分泌和旁分泌信号介导，在微生物基因组或表观遗传因素的影响下引起体细胞的变化。在与癌症有关的感染源中，人类乳头瘤病毒(HPV)的某些基因类型尤为突出。人乳头瘤病毒几乎是所有宫颈癌的罪魁祸首，而阴道癌、外阴癌、肛门癌、阴茎癌和一些外生殖道癌的比例较低。本文就炎症反应机制的最新进展及其在肿瘤发生过程中的作用作一综述，强调慢性炎症在HPV诱导的宫颈癌发生发展中的作用。
Inflammation is a defense strategy against invading agents and harmful molecules that is activated immediately following a stimulus, and involves the release of cytokines and chemokines, which activate the innate immune response. These mediators act together to increase blood flow and vascular permeability, facilitating recruitment of effector cells to the site of injury. Following resolution of the injury and removal of the stimulus, inflammation is disabled, but if the stimulus persists, inflammation becomes chronic and is strongly associated with cancer. This is likely to be due to the fact that the inflammation leads to a wound that does not heal, requiring a constant renewal of cells, which increases the risk of neoplastic transformation. Debris from phagocytosis, including the reactive species of oxygen and nitrogen that cause damage to DNA already damaged by the leukotrienes and prostaglandins, has an impact on inflammation and various carcinogenic routes. There is an association between chronic inflammation, persistent infection and cancer, where oncogenic action is mediated by autocrine and paracrine signals, causing changes in somatic cells under the influence of the microbial genome or of epigenetic factors. Among the infectious agents associated with cancer, certain genotypes of human papillomavirus (HPV) stand out. HPV is responsible for virtually all cases of cervical cancer and a lower proportion of cancers of the vagina, vulva, anus, penis and a number of extragenital cancers. In the present review, recent advances in the mechanisms involved in the inflammatory response are presented with their participation in the process of carcinogenesis, emphasizing the role of chronic inflammation in the development of HPV-induced cervical cancer.
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影响因子：
3.2
作者：
Friedman, R;Hughes, AL
通讯作者：
Hughes, AL
DOI：
10.1080/09540120600966182
发表时间：
2007-02-01
影响因子：
1.7
作者：
Anthony, M. N.;Gardner, L.;Loughlin, A. M.
通讯作者：
Loughlin, A. M.
影响因子：
8.7
作者：
Graham BS
通讯作者：
Graham BS
影响因子：
4.4
作者：
Cho, Mi-La;Kang, Jung-Won;Kim, Ho-Youn
通讯作者：
Kim, Ho-Youn
DOI：
10.1038/nrg2634
发表时间：
2009-10
期刊：
Nature reviews. Genetics
影响因子：
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作者：
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