Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts.
Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts.
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DOI：
10.1038/sj.bjc.6602868
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发表时间：
2005-11-28
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
我们在瑞典乳腺X线摄影队列和瑞典男性队列中，对37147名女性和45906名男性进行了560666人年的随访，研究了体重指数（BMI）、腰围、糖尿病史和吸烟与胰腺癌风险的关系;诊断出136例胰腺癌病例。与BMI为20-25 kg/m2的患者相比，肥胖女性和男性（BMI <30 kg/m2）胰腺癌的多变量率比（RR）为1.81（95% CI：1.04-3.15）。对于腰围差异20 cm（约两个标准差），女性的多变量RR为1.32（95% CI：0.73-2.37），男性为1.74（95% CI：1.00-3.01）。胰腺癌风险与糖尿病史（多变量RR：1.88; 95%CI：1.09-3.26）和吸烟史（目前与从不吸烟者相比的多变量RR：3.06; 95%CI：1.99-4.72）相关。与从不吸烟的人相比，目前吸烟140包-年的人的风险增加了5倍。戒烟后5-10年内，既往吸烟者的风险接近从不吸烟者的RR。这项前瞻性研究的结果支持总体肥胖、腹部肥胖、糖尿病和吸烟与胰腺癌风险的正相关关系。
We examined the associations of body mass index (BMI), waist circumference, a history of diabetes, and cigarette smoking with risk of pancreatic cancer among 37 147 women and 45 906 men followed up during 560 666 person-years in the Swedish Mammography Cohort and the Cohort of Swedish Men; 136 incident cases of pancreatic cancer were diagnosed. The multivariate rate ratio (RR) of pancreatic cancer for obese women and men (BMI ⩾30 kg/m2) was 1.81 (95% CI: 1.04–3.15) compared to those with a BMI of 20–25 kg/m2. For a difference of 20 cm (about two standard deviations) in waist circumference, the multivariate RRs were 1.32 (95% CI: 0.73–2.37) among women and 1.74 (95% CI: 1.00–3.01) among men. Pancreatic cancer risk was associated with history of diabetes (multivariate RR: 1.88; 95% CI: 1.09–3.26) and cigarette smoking (multivariate RR for current compared with never smokers: 3.06; 95% CI: 1.99–4.72). Current smokers of ⩾40 pack-years had a five-fold elevated risk compared with never smokers. Risk among past smokers approached the RR for never smokers within 5–10 years following smoking cessation. Findings from this prospective study support positive relationships of overall obesity, abdominal adiposity, diabetes and smoking with risk of pancreatic cancer.
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影响因子：
8.8
作者：
通讯作者：
--
影响因子：
15.9
作者：
Kahn, BB;Flier, JS
通讯作者：
Flier, JS
影响因子：
50.5
作者：
Boyle, P;Ferlay, J
通讯作者：
Ferlay, J
影响因子：
3.8
作者：
Patel, AV;Rodriguez, C;Calle, EE
通讯作者：
Calle, EE
影响因子：
2.3
作者：
Samanic, C;Gridley, G;Fraumeni, JF
通讯作者：
Fraumeni, JF