Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals.
Genetic variation in the prostate stem cell antigen gene and upper gastrointestinal cancer in white individuals.
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白人前列腺干细胞抗原基因的遗传变异与上消化道癌。
DOI：
10.1053/j.gastro.2010.11.001
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发表时间：
2011-02
期刊：
影响因子：
29.4
通讯作者：
El-Omar EM
中科院分区：
文献类型：
--
作者：
Lochhead P;Frank B;Hold GL;Rabkin CS;Ng MT;Vaughan TL;Risch HA;Gammon MD;Lissowska J;Weck MN;Raum E;Müller H;Illig T;Klopp N;Dawson A;McColl KE;Brenner H;Chow WH;El-Omar EM
据报道，在一些亚洲人群中，胃癌与前列腺干细胞抗原（PSCA）基因的rs 2294008（C>T）多态性之间存在关联。我们着手确定这种关联是否存在于高加索人中。我们对166名胃癌患者的亲属进行了基因分型，其中包括43名幽门螺杆菌感染的低氯血症和胃萎缩受试者，65名感染的受试者没有这些异常，58名幽门螺杆菌阴性的亲属和100名对照人群。此外，一项基于人群的慢性萎缩性胃炎研究提供了533例病例和1054例对照。然后，我们进行了2项基于人群的上消化道癌病例对照研究：第一项研究包括312例胃癌病例和383例对照;第二项研究包括309例胃癌病例，159例食管癌病例和211例对照。根据逻辑模型计算比值比，并针对混杂变量进行调整。PSCA中rs 2294008风险等位基因（T）的携带与慢性萎缩性胃炎（校正比值比[OR] = 1.5; 95%置信区间[CI]，1.1-1.9）和非贲门胃癌（OR = 1.9; 95% CI，1.3- 2.8）相关。弥漫性组织学类型的相关性最强（OR = 3.2; 95%CI，1.2-10.7）。携带该危险等位基因与贲门癌（OR = 0.5; 95%CI，0.3-0.9）、食管腺癌（OR = 0.5; 95%CI，0.3-0.9）和食管鳞状细胞癌（OR = 0.4; 95%CI，0.2-0.9）呈负相关。PSCA的rs 2294008多态性增加了高加索人非贲门胃癌及其前体的风险，但对近端癌有保护作用。
An association between gastric cancer and the rs2294008 (C>T) polymorphism in the prostate stem cell antigen (PSCA) gene has been reported for several Asian populations. We set out to determine whether such an association exists in Caucasians. We genotyped 166 relatives of gastric cancer patients, including 43 H pylori-infected subjects with hypochlorhydria and gastric atrophy, 65 infected subjects without these abnormalities, 58 H pylori-negative relatives, and 100 population controls. Additionally, a population-based study of chronic atrophic gastritis provided 533 cases and 1054 controls. We then genotyped 2 population-based case-control studies of upper gastrointestinal cancer: the first included 312 gastric cancer cases and 383 controls; the second included 309 gastric cancer cases, 159 esophageal cancer cases, and 211 controls. Odds ratios were computed from logistic models and adjusted for confounding variables. Carriage of the risk allele (T) of rs2294008 in PSCA was associated with chronic atrophic gastritis (adjusted odds ratio [OR] = 1.5; 95% confidence interval [CI], 1.1–1.9) and non-cardia gastric cancer (OR = 1.9; 95% CI, 1.3– 2.8). The association was strongest for the diffuse histological-type (OR = 3.2; 95% CI, 1.2–10.7). An inverse association was observed between carriage of the risk allele and gastric cardia cancer (OR = 0.5; 95% CI, 0.3–0.9), esophageal adenocarcinoma (OR = 0.5; 95% CI, 0.3–0.9), and esophageal squamous cell carcinoma (OR = 0.4; 95% CI, 0.2–0.9). The rs2294008 polymorphism in PSCA increases the risk of non-cardia gastric cancer and its precursors in Caucasians but protects against proximal cancers.
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DOI：
10.1523/jneurosci.2271-09.2009
发表时间：
2009-11-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hruska M;Keefe J;Wert D;Tekinay AB;Hulce JJ;Ibañez-Tallon I;Nishi R
通讯作者：
Nishi R
DOI：
10.1006/bbrc.2000.3393
发表时间：
2000-09-07
影响因子：
3.1
作者：
Bahrenberg, G;Brauers, A;Jakse, G
通讯作者：
Jakse, G
影响因子：
8
作者：
Gu, Z;Thomas, G;Reiter, RE
通讯作者：
Reiter, RE
影响因子：
11.2
作者：
Gao, Lei;Weck, Melanie N.;Brenner, Hermann
通讯作者：
Brenner, Hermann
影响因子：
10.3
作者：
Gammon, MD;Schoenberg, JB;Fraumeni, JF
通讯作者：
Fraumeni, JF