Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study.
Adult obesity susceptibility variants are associated with greater childhood weight gain and a faster tempo of growth: the 1946 British Birth Cohort Study.
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DOI：
10.3945/ajcn.111.027870
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发表时间：
2012-05
期刊：
影响因子：
--
通讯作者：
Ong KK
中科院分区：
文献类型：
--
作者：
Elks CE;Loos RJ;Hardy R;Wills AK;Wong A;Wareham NJ;Kuh D;Ong KK
背景资料：纵向生长与成人BMI的遗传变异的关联可能为肥胖易感性的时间提供见解。目的：目的是探索已知的BMI位点与出生到成年的身体尺寸测量的关联。设计图：对来自英国纵向出生队列的2537名个体进行了11种与成人BMI密切相关的遗传变异的基因分型（FTO内/附近，MC 4 R，TMEM 18，GNPDA 2，KCTD 15，NEGR 1，BDNF，ETV 5，SEC 16 B，SH 2B 1和MTCH 2）。我们推导出肥胖风险等位基因评分，包括每个个体中BMI增加等位基因的总和，并检查其与出生体重和2岁至53岁之间11个时间点的体重，身高和BMI SD评分（SDS）的重复测量的相关性。结果如下：肥胖风险等位基因评分显示与出生体重（0.019 SDS/等位基因; P = 0.05）的边缘显著相关，并且在2岁至53岁的所有时间点与较高的体重和BMI更明显相关;与体重的最强关联发生在11岁和20岁（均为0.056 SDS/等位基因）。在纵向分析中，该评分仅与出生至11岁之间的体重增加呈正相关（0.003 SDS/等位基因每年; 95% CI：0.001，0.004; P = 0.001）。风险等位基因评分与7岁时身高增高（0.031 SDS/等位基因; P = 0.002）和2 - 7岁之间身高增加（0.007 SDS/等位基因每年; P < 0.001）相关，但与成年身高无关（P = 0.5）。结论：成人肥胖易感性变异体对体重增加的综合影响仅限于儿童期。这些变体赋予了更快的克里思的身高增长，这是明显的青春期前几年。
Background: Longitudinal growth associations with genetic variants identified for adult BMI may provide insights into the timing of obesity susceptibility. Objective: The objective was to explore associations of known BMI loci with measures of body size from birth to adulthood. Design: A total of 2537 individuals from a longitudinal British birth cohort were genotyped for 11 genetic variants robustly associated with adult BMI (in/near FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, ETV5, SEC16B, SH2B1, and MTCH2). We derived an obesity-risk-allele score, comprising the sum of BMI-increasing alleles in each individual, and examined this for an association with birth weight and repeated measures of weight, height, and BMI SD scores (SDS) at 11 time points between ages 2 and 53 y. Results: The obesity-risk-allele score showed borderline significant association with birth weight (0.019 SDS/allele; P = 0.05) and was more clearly associated with higher weight and BMI at all time points between ages 2 and 53 y; the strongest associations with weight occurred at ages 11 and 20 y (both 0.056 SDS/allele). In longitudinal analyses, the score was positively associated with weight gain only between birth and 11 y (0.003 SDS/allele per year; 95% CI: 0.001, 0.004; P = 0.001). The risk-allele score was associated with taller height at 7 y (0.031 SDS/allele; P = 0.002) and greater height gains between 2 and 7 y (0.007 SDS/allele per year; P < 0.001), but not with adult height (P = 0.5). Conclusions: The combined effect of adult obesity susceptibility variants on weight gain was confined to childhood. These variants conferred a faster tempo of height growth that was evident before the pubertal years.
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影响因子：
30.8
作者：
通讯作者：
--
影响因子：
3.7
作者：
Andersson EA;Pilgaard K;Pisinger C;Harder MN;Grarup N;Færch K;Sandholt C;Poulsen P;Witte DR;Jørgensen T;Vaag A;Pedersen O;Hansen T
通讯作者：
Hansen T
影响因子：
--
作者：
Parsons, TJ;Power, C;Manor, O
通讯作者：
Manor, O
影响因子：
7.7
作者：
den Hoed M;Ekelund U;Brage S;Grontved A;Zhao JH;Sharp SJ;Ong KK;Wareham NJ;Loos RJ
通讯作者：
Loos RJ
影响因子：
2
作者：
COLE, TJ;GREEN, PJ
通讯作者：
GREEN, PJ