Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals.
Do gene variants influencing adult adiposity affect birth weight? A population-based study of 24 loci in 4,744 Danish individuals.
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DOI：
10.1371/journal.pone.0014190
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发表时间：
2010-12-01
期刊：
影响因子：
3.7
通讯作者：
Hansen T
中科院分区：
文献类型：
--
作者：
Andersson EA;Pilgaard K;Pisinger C;Harder MN;Grarup N;Færch K;Sandholt C;Poulsen P;Witte DR;Jørgensen T;Vaag A;Pedersen O;Hansen T
最近的全基因组关联研究已经确定了几个影响成人肥胖的肥胖风险等位基因。我们的目的是研究这些变异体对胎儿身体成分的潜在影响，通过调查的变异体的新生儿的出生体重和体重指数。来自丹麦国家档案馆的助产士记录提供了关于母亲年龄、产次以及出生体重、出生身长和新生儿早产的信息，这些信息来自基于人群的Inter 99研究的4,744名个体。对24个与成人BMI和/或腰围有全基因组关联的危险等位基因进行基因分型。在多重检验校正后，检测的24种风险变异中没有一种与出生体重或体重指数相关。将出生体重分为三类：低出生体重（≤第10百分位数）、正常出生体重（第10 - 90百分位数）和高出生体重（≥第90百分位数），以考虑非线性相关性。两组之间的风险等位基因数量没有差异（p = 0.57）。 未观察到每个危险等位基因和出生体重在预测成人BMI中的相互作用。通过总结风险等位基因来创建肥胖风险评分。风险评分与胎儿身体成分无关。此外，风险评分和出生体重/体重指数在预测成人BMI方面没有相互作用。与成人肥胖相关的24种常见变异不影响丹麦人的出生体重或与出生体重相互作用，这表明这些变异的影响主要发生在出生后。
Several obesity risk alleles affecting adult adiposity have been identified by the recent wave of genome wide association studies. We aimed to examine the potential effect of these variants on fetal body composition by investigating the variants in relation to birth weight and ponderal index of the newborn. Midwife records from the Danish State Archives provided information on mother's age, parity, as well as birth weight, birth length and prematurity of the newborn in 4,744 individuals of the population-based Inter99 study. Twenty-four risk alleles showing genome-wide associations with adult BMI and/or waist circumference were genotyped. None of the 24 risk variants tested showed an association with birth weight or ponderal index after correction for multiple testing. Birth weight was divided into three categories low (≤10th percentile), normal (10th–90th percentile) and high birth weight (≥90th percentile) to allow for non-linear associations. There was no difference in the number of risk alleles between the groups (p = 0.57). No interactions between each risk allele and birth weight in the prediction of adult BMI were observed. An obesity risk score was created by summing up risk alleles. The risk score did not associate with fetal body composition. Moreover there was no interaction between the risk score and birth weight/ponderal index in the prediction of adult BMI. 24 common variants associated with adult adiposity did not affect or interact with birth weight among Danes suggesting that the effects of these variants predominantly arise in the post-natal life.
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影响因子：
4.5
作者：
Heard-Costa NL;Zillikens MC;Monda KL;Johansson A;Harris TB;Fu M;Haritunians T;Feitosa MF;Aspelund T;Eiriksdottir G;Garcia M;Launer LJ;Smith AV;Mitchell BD;McArdle PF;Shuldiner AR;Bielinski SJ;Boerwinkle E;Brancati F;Demerath EW;Pankow JS;Arnold AM;Chen YD;Glazer NL;McKnight B;Psaty BM;Rotter JI;Amin N;Campbell H;Gyllensten U;Pattaro C;Pramstaller PP;Rudan I;Struchalin M;Vitart V;Gao X;Kraja A;Province MA;Zhang Q;Atwood LD;Dupuis J;Hirschhorn JN;Jaquish CE;O'Donnell CJ;Vasan RS;White CC;Aulchenko YS;Estrada K;Hofman A;Rivadeneira F;Uitterlinden AG;Witteman JC;Oostra BA;Kaplan RC;Gudnason V;O'Connell JR;Borecki IB;van Duijn CM;Cupples LA;Fox CS;North KE
通讯作者：
North KE
影响因子：
30.8
作者：
Chambers, John C.;Elliott, Paul;Kooner, Jaspal S.
通讯作者：
Kooner, Jaspal S.
影响因子：
3.5
作者：
Liu, Yong-Jun;Liu, Xiao-Gang;Deng, Hong-Wen
通讯作者：
Deng, Hong-Wen
FTO 基因与人类脂肪量之间的关联在出生后两周内形成
影响因子：
5.8
作者：
Lopez-Bermejo, Abel;Petry, Clive J.;Ibanez, Lourdes
通讯作者：
Ibanez, Lourdes
DOI：
10.1097/mpg.0b013e3181977375
发表时间：
2009-03-01
影响因子：
2.9
作者：
Bouret, Sebastien G.
通讯作者：
Bouret, Sebastien G.