Presynaptic gating of postsynaptic synaptic plasticity: a plasticity filter in the adult auditory cortex.
Presynaptic gating of postsynaptic synaptic plasticity: a plasticity filter in the adult auditory cortex.
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DOI：
10.1177/1073858413482983
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Zakharenko SS
中科院分区：
文献类型：
--
作者：
Blundon JA;Zakharenko SS
感觉皮层不仅可以检测和分析传入的感觉信息，还可以在学习行为上重要的感觉线索时经历可塑性变化。这种经验依赖的皮层可塑性对于塑造和修改神经元回路以执行多种先前未知的感觉的计算是必不可少的，这种适应性过程被认为是感知学习的基础。对皮层可塑性机制的深入研究提供了一些重要的线索;然而，皮层可塑性背后的复杂神经网络中的确切细胞位点和机制尚未阐明。在这篇综述中，我们提出了几个相似之处之间的皮层可塑性在听觉皮层和最近发现的机制，突触可塑性门控丘脑皮质的预测，提供主要的输入到感觉皮层。丘脑皮层突触可塑性的特点和机制之间的惊人的相似性和经验依赖的皮层可塑性在听觉皮层，特别是在早期的关键时期的监管方面，点丘脑皮层的预测作为一个重要的位点的可塑性在感觉皮层。
Sensory cortices can not only detect and analyze incoming sensory information but can also undergo plastic changes while learning behaviorally important sensory cues. This experience-dependent cortical plasticity is essential for shaping and modifying neuronal circuits to perform computations of multiple, previously unknown sensations, the adaptive process that is believed to underlie perceptual learning. Intensive efforts to identify the mechanisms of cortical plasticity have provided several important clues; however, the exact cellular sites and mechanisms within the intricate neuronal networks that underlie cortical plasticity have yet to be elucidated. In this review, we present several parallels between cortical plasticity in the auditory cortex and recently discovered mechanisms of synaptic plasticity gating at thalamocortical projections that provide the main input to sensory cortices. Striking similarities between the features and mechanisms of thalamocortical synaptic plasticity and those of experience-dependent cortical plasticity in the auditory cortex, especially in terms of regulation of an early critical period, point to thalamocortical projections as an important locus of plasticity in sensory cortices.
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影响因子：
5.3
作者：
Blundon, Jay A.;Bayazitov, Ildar T.;Zakharenko, Stanislav S.
通讯作者：
Zakharenko, Stanislav S.
影响因子：
64.8
作者：
CRAIR, MC;MALENKA, RC
通讯作者：
MALENKA, RC
影响因子：
5.3
作者：
Bayazitov, Ildar T.;Richardson, Robert J.;Zakharenko, Stanislav S.
通讯作者：
Zakharenko, Stanislav S.
影响因子：
1.9
作者：
Bjordahl, TS;Dimyan, MA;Weinberger, NM
通讯作者：
Weinberger, NM
影响因子：
25
作者：
Boyden, ES;Zhang, F;Deisseroth, K
通讯作者：
Deisseroth, K